Upregulation of long noncoding RNA MIAT in aggressive form of chronic lymphocytic leukemias

Sattari, Arash; Siddiqui, Hasan; Moshiri, Farzaneh; Ngankeu, Apollinaire; Nakamura, Tatsuya; Kipps, Thomas J.; Croce, Carlo M.

doi:10.18632/oncotarget.11099

Cited by 77 publications

(83 citation statements)

References 14 publications

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“…In addition, Shen et al [18] found that the downregulation of MIAT leads to reduced survival of lens epithelial cells in cataract patients. In a cancerous context, Sattari et al [20] found that siRNA-mediated suppression led to increased apoptosis in malignant B cells in patients with aggressive chronic lymphocytic leukaemia, while a recent study has revealed augmented basal apoptosis in various breast cancer cell lines in response to MIAT downregulation [43].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, MIAT is polyadenylated at the 3' end and has at least 4 and 10 alternatively spliced variants for human and mouse, respectively [12], [16]. MIAT is thought to participate in pre-mRNA splicing through its binding to splicing factor 1 (SF1), although this interaction is not essential for the localisation of MIAT [19], as well as various cancers, including CLL (chronic lymphocytic leukaemia) and DLBL (diffuse large B-cell lymphoma) [20].…”

Section: Point 10mentioning

confidence: 99%

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RNA sequencing reveals a key role for the long non-coding RNA MIAT in regulating neuroblastoma and glioblastoma cell fate

Bountali

Tonge

Mourtada-Maarabouni

2019

International Journal of Biological Macromolecules

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Myocardial Infraction Associated Transcript (MIAT) is a subnuclear lncRNA that interferes with alternative splicing and is associated with increased risk of various heart conditions and nervous system tumours. The current study aims to elucidate the role of MIAT in cell survival, apoptosis and migration in neuroblastoma and glioblastoma multiforme. To this end, MIAT was silenced by MIAT-specific siRNAs in neuroblastoma and glioblastoma cell lines, and RNA sequencing together with a series of functional assays were performed. The RNA sequencing has revealed that the expression of an outstanding number of genes is altered, including genes involved in cancer-related processes, such as cell growth and survival, apoptosis, reactive oxygen species (ROS) production and migration. Furthermore, the functional studies have confirmed the RNA sequencing leads, with our key findings suggesting that MIAT knockdown eliminates long-term survival and migration and increases basal apoptosis in neuroblastoma and glioblastoma cell lines. Taken together with the recent demonstration of the involvement of MIAT in glioblastoma, our observations suggest that MIAT could possess tumour-promoting properties, thereby acting as an oncogene, and has the potential to be used as a reliable biomarker for neuroblastoma and glioblastoma and be employed for prognostic, predictive and, potentially, therapeutic purposes for these cancers.

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Section: Discussionmentioning

confidence: 99%

Section: Point 10mentioning

confidence: 99%

RNA sequencing reveals a key role for the long non-coding RNA MIAT in regulating neuroblastoma and glioblastoma cell fate

Bountali

Tonge

Mourtada-Maarabouni

2019

International Journal of Biological Macromolecules

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“…Further, it was then found to be dysregulated in cataract (Shen et al, 2016), non-small-cell lung cancer (H. Y. Zhang, Zheng, Yang, & Lu, 2017), neuroendocrine prostate cancer (Crea et al, 2016), and chronic lymphocytic leukemias (Sattari et al, 2016).…”

Section: Lncrna H19/mir-152/mrna Dnmt1mentioning

confidence: 99%

Competing endogenous RNA (ceRNA) cross talk and language in ceRNA regulatory networks: A new look at hallmarks of breast cancer

Abdollahzadeh

Daraei

Mansoori

et al. 2018

Journal Cellular Physiology

229

185

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Breast cancer (BC) is the most frequently occurring malignancy in women worldwide. Despite the substantial advancement in understanding the molecular mechanisms and management of BC, it remains the leading cause of cancer death in women. One of the main reasons for this obstacle is that we have not been able to find the Achilles heel for the BC as a highly heterogeneous disease. Accumulating evidence has revealed that noncoding RNAs (ncRNAs), play key roles in the development of BC; however, the involving of complex regulatory interactions between the different varieties of ncRNAs in the development of this cancer has been poorly understood. In the recent years, the newly discovered mechanism in the RNA world is “competing endogenous RNA (ceRNA)” which proposes regulatory dialogues between different RNAs, including long ncRNAs (lncRNAs), microRNAs (miRNAs), transcribed pseudogenes, and circular RNAs (circRNAs). In the latest BC research, various studies have revealed that dysregulation of several ceRNA networks (ceRNETs) between these ncRNAs has fundamental roles in establishing the hallmarks of BC development. And it is thought that such a discovery could open a new window for a better understanding of the hidden aspects of breast tumors. Besides, it probably can provide new biomarkers and potential efficient therapeutic targets for BC. This review will discuss the existing body of knowledge regarding the key functions of ceRNETs and then highlights the emerging roles of some recently discovered ceRNETs in several hallmarks of BC. Moreover, we propose for the first time the “ceRnome” as a new term in the present article for RNA research.

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“…Crea et al found that MIAT is selectively up-regulated in neuroendocrine prostate cancer and may interact with polycomb genes [16]. A study conducted by Sattari et al showed that MIAT forms a regulatory loop with OCT4 in malignant mature B cells [17]. However, how MIAT functions in ccRCC pathogenesis remains highly unspecified.…”

Section: Introductionmentioning

confidence: 99%

Upregulation of MIAT Regulates LOXL2 Expression by Competitively Binding MiR-29c in Clear Cell Renal Cell Carcinoma

Qü¹,

Xiao²,

Xiao³

et al. 2018

Cell Physiol Biochem

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Background/Aims: MIAT is a long noncoding RNA (lncRNA) involved in cell proliferation and the development of tumor. However, the exact effects and molecular mechanisms of MIAT in clear cell renal cell carcinoma (ccRCC) progression are still unknown. Methods: We screened the lncRNAs’ profile of ccRCC in The Cancer Genome Atlas database, and then examined the expression levels of lncRNA MIAT in 45 paired ccRCC tissue specimens and in cell lines by q-RT-PCR. MTS, colony formation, EdU, and Transwell assays were performed to examine the effect of MIAT on proliferation and metastasis of ccRCC. Western blot and luciferase assays were performed to determine whether MIAT can regulate Loxl2 expression by competitively binding miR-29c in ccRCC. Results: MIAT was up-regulated in ccRCC tissues and cell lines. High MIAT expression correlated with worse clinicopathological features and shorter survival rate. Functional assays showed that knockdown of MIAT inhibited renal cancer cell proliferation and metastasis in vitro and in vivo. Luciferase and western blot assays further confirmed that miR-29c binds with MIAT. Additionally, the correlation of miR-29c with MIAT and Loxl2 was further verified in patients' samples. Conclusion: Our data indicated that MIAT might be an oncogenic lncRNA that promoted proliferation and metastasis of ccRCC, and could be a potential therapeutic target in human ccRCC.

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Upregulation of long noncoding RNA MIAT in aggressive form of chronic lymphocytic leukemias

Cited by 77 publications

References 14 publications

RNA sequencing reveals a key role for the long non-coding RNA MIAT in regulating neuroblastoma and glioblastoma cell fate

RNA sequencing reveals a key role for the long non-coding RNA MIAT in regulating neuroblastoma and glioblastoma cell fate

Competing endogenous RNA (ceRNA) cross talk and language in ceRNA regulatory networks: A new look at hallmarks of breast cancer

Upregulation of MIAT Regulates LOXL2 Expression by Competitively Binding MiR-29c in Clear Cell Renal Cell Carcinoma

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