“…It has been shown that lncRNA SOX2-OT is overexpressed in a number of human cancers as an oncogene promoting tumorigenesis and cancer progression, including ovarian cancer, breast cancer, pancreatic ductal adenocarcinoma, cholangiocarcinoma, hepatocellular carcinoma, esophageal squamous cell carcinoma, osteosarcoma, non-small cell lung cancer, and gastric cancer (Iranpour et al, 2016;Zhang et al, 2016;Zou et al, 2016;Wang et al, 2017a;Wang et al, 2017b;Han et al, 2018;Li et al, 2018a;Li et al, 2018b;Sun et al, 2018;Tian et al, 2018;Wei et al, 2018;Xie et al, 2018). SOX2-OT is co-upregulated with SOX2 and OCT4 in esophageal squamous cell carcinoma and potentially involved in maintaining the pluripotent state of stem cells (Shahryari et al, 2014).…”