Upregulation of KAT2B and ESCO2 gene expression level in patients with rheumatoid arthritis

Ghasemi, Alaleh; Farazmand, Ali; Hassan‐Zadeh, Vahideh; Poursani, Shiva; Soltani, Shahin; Akhtari, Maryam; Akhlaghi, Maassoumeh; Farhadi, Elham; Jamshidi, Ahmadreza; Mahmoudi, Mahdi

doi:10.1007/s10067-022-06351-4

Cited by 2 publications

(2 citation statements)

References 28 publications

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“…Consistent with our findings, the HDAC KAT2B gene is also upregulated in PBMCs from rheumatoid arthritis patients [79], and its overexpression increases histone H4 acetylation on the enhancer of MHC class I promoters [80]. It is nevertheless also important in Treg cell development [68,81,82].…”

Section: Discussionsupporting

confidence: 89%

Genetic Association and Differential RNA Expression of Histone (De)Acetylation-Related Genes in Pemphigus Foliaceus—A Possible Epigenetic Effect in the Autoimmune Response

Sulzbach Denardin,

Bumiller-Bini Hoch,

Salviano-Silva

et al. 2023

Life

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Pemphigus foliaceus (PF) is an autoimmune skin blistering disease characterized by antidesmoglein-1 IgG production, with an endemic form (EPF) in Brazil. Genetic and epigenetic factors have been associated with EPF, but its etiology is still not fully understood. To evaluate the genetic association of histone (de)acetylation-related genes with EPF susceptibility, we evaluated 785 polymorphisms from 144 genes, for 227 EPF patients and 194 controls. Carriers of HDAC4_rs4852054*A were more susceptible (OR = 1.79, p = 0.0038), whereas those with GSE1_rs13339618*A (OR = 0.57, p = 0.0011) and homozygotes for PHF21A_rs4756055*A (OR = 0.39, p = 0.0006) were less susceptible to EPF. These variants were not associated with sporadic PF (SPF) in German samples of 75 SPF patients and 150 controls, possibly reflecting differences in SPF and EPF pathophysiology. We further evaluated the expression of histone (de)acetylation-related genes in CD4+ T lymphocytes, using RNAseq. In these cells, we found a higher expression of KAT2B, PHF20, and ZEB2 and lower expression of KAT14 and JAD1 in patients with active EPF without treatment compared to controls from endemic regions. The encoded proteins cause epigenetic modifications related to immune cell differentiation and cell death, possibly affecting the immune response in patients with PF.

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Section: Discussionsupporting

confidence: 89%

Genetic Association and Differential RNA Expression of Histone (De)Acetylation-Related Genes in Pemphigus Foliaceus—A Possible Epigenetic Effect in the Autoimmune Response

Sulzbach Denardin,

Bumiller-Bini Hoch,

Salviano-Silva

et al. 2023

Life

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“…The results revealed that C4 is associated with high expression of K00620 in the lysine biosynthesis pathway, corresponding to amino-acid N-acetyltransferase [EC:2.3.1.35 2.3.1.1]. Amino acid acetyltransferase can transfer the acetyl group in acetyl-CoA to the amino group in the amino acid molecule and is a key enzyme in lysine bio-anabolism (Liu et al, 2022 ; Ghasemi et al, 2023 ). As an essential amino acid for infants, lysine plays an important role in regulating the physiological activity of intestinal epithelial cells and inhibiting the colonization of harmful bacteria (Wang et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

Short-chain fatty acids in breast milk and their relationship with the infant gut microbiota

Xi,

Yan,

Duan

et al. 2024

Front. Microbiol.

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IntroductionThe short-chain fatty acids (SCFAs) contained in breast milk play a key role in infant growth, affecting metabolism and enhancing intestinal immunity by regulating inflammation.MethodsIn order to examine the associations between the microbiota and SCFA levels in breast milk, and explore the roles of SCFAs in regulating the infant gut microbiota, we enrolled 50 paired mothers and infants and collected both breast milk and infant fecal samples. Breast milk SCFA contents were determined by UPLC-MS, and whole genome shotgun sequencing was applied to determine the microbial composition of breast milk and infant feces. The SCFA levels in breast milk were grouped into tertiles as high, medium, or low, and the differences of intestinal microbiota and KEGG pathways were compared among groups.ResultsThe results demonstrated that breast milk butyric acid (C4) is significantly associated with Clostridium leptum richness in breastmilk. Additionally, the specific Bifidobacterium may have an interactive symbiosis with the main species of C4-producing bacteria in human milk. Women with a low breast milk C4 tertile are associated with a high abundance of Salmonella and Salmonella enterica in their infants' feces. KEGG pathway analysis further showed that the content of C4 in breast milk is significantly correlated with the infants' metabolic pathways of lysine and arginine biosynthesis.DiscussionThis study suggests that interactive symbiosis of the microbiota exists in breast milk. Certain breast milk microbes could be beneficial by producing C4 and further influence the abundance of certain gut microbes in infants, playing an important role in early immune and metabolic development.

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Upregulation of KAT2B and ESCO2 gene expression level in patients with rheumatoid arthritis

Cited by 2 publications

References 28 publications

Genetic Association and Differential RNA Expression of Histone (De)Acetylation-Related Genes in Pemphigus Foliaceus—A Possible Epigenetic Effect in the Autoimmune Response

Genetic Association and Differential RNA Expression of Histone (De)Acetylation-Related Genes in Pemphigus Foliaceus—A Possible Epigenetic Effect in the Autoimmune Response

Short-chain fatty acids in breast milk and their relationship with the infant gut microbiota

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