Upregulation of FOXP3 may act on immunological misbalance in Turner syndrome

Abstract

Turner syndrome (TS) presents a characteristic immune imbalance among patients. As the X chromosome-linked FOXP3 gene is a powerful immune regulator, in this work we investigated a possible relationship between FOXP3 and TS.We evaluated 117 TS patients to investigate whether genetic associations within polymorphisms in FOXP3 (rs3761548, rs3761549) were associated with immune conditions. TaqMan Assays genotyping probes were employed in a real-time PCR-based method. Subsequently, we compared FOXP3 mRNA expression lev-