Upregulation of <i>Arc</i> mRNA expression in the prefrontal cortex following cue‐induced reinstatement of extinguished cocaine‐seeking behavior

Zavala, Arturo R.; Osredkar, Tracy; Joyce, Jeffrey N.; Neisewander, Janet L.

doi:10.1002/syn.20502

Cited by 62 publications

(60 citation statements)

References 99 publications

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“…These findings expand upon our previous study (Lasseter et al, 2011), in which BM-induced functional disconnection of the OFC and BLA inhibited drug context-induced reinstatement of cocaine-seeking behavior without altering food-reinforced instrumental responding or general motor activity. These findings also add to a larger literature that indicates that the OFC and BLA are critical for explicit cue-and drug context-induced cocaine-seeking behaviors (Atkins et al, 2008;Crombag et al, 2008;Fuchs et al, 2005Fuchs et al, , 2004Fuchs et al, , 2008Grimm and See, 2000;Hamlin et al, 2008;Kantak et al, 2002;Lasseter et al, 2009Lasseter et al, , 2011McLaughlin and See, 2003;Neisewander et al, 2000;See et al, 2001;Zavala et al, 2008).…”

Section: Discussionsupporting

confidence: 62%

Contribution of a Mesocorticolimbic Subcircuit to Drug Context-Induced Reinstatement of Cocaine-Seeking Behavior in Rats

Lasseter

Xie

Arguello

et al. 2013

Neuropsychopharmacol

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Cocaine-seeking behavior triggered by drug-paired environmental context exposure is dependent on orbitofrontal cortex (OFC)-basolateral amygdala (BLA) interactions. Here, we present evidence supporting the hypothesis that dopaminergic input from the ventral tegmental area (VTA) to the OFC critically regulates these interactions. In experiment 1, we employed site-specific pharmacological manipulations to show that dopamine D1-like receptor stimulation in the OFC is required for drug context-induced reinstatement of cocaine-seeking behavior following extinction training in an alternate context. Intra-OFC pretreatment with the dopamine D1-like receptor antagonist, SCH23390, dose-dependently attenuated cocaine-seeking behavior in an anatomically selective manner, without altering motor performance. Furthermore, the effects of SCH23390 could be surmounted by co-administration of a sub-threshold dose of the D1-like receptor agonist, SKF81297. In experiment 2, we examined effects of D1-like receptor antagonism in the OFC on OFC-BLA interactions using a functional disconnection manipulation. Unilateral SCH23390 administration into the OFC plus GABA agonist-induced neural inactivation of the contralateral or ipsilateral BLA disrupted drug context-induced cocaine-seeking behavior relative to vehicle, while independent unilateral manipulations of these brain regions were without effect. Finally, in experiment 3, we used fluorescent retrograde tracers to demonstrate that the VTA, but not the substantia nigra, sends dense intra-and interhemispheric projections to the OFC, which in turn has reciprocal bi-hemispheric connections with the BLA. These findings support that dopaminergic input from the VTA, via dopamine D1-like receptor stimulation in the OFC, is required for OFC-BLA functional interactions. Thus, a VTA-OFC-BLA neural circuit promotes drug context-induced motivated behavior.

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Section: Discussionsupporting

confidence: 62%

Contribution of a Mesocorticolimbic Subcircuit to Drug Context-Induced Reinstatement of Cocaine-Seeking Behavior in Rats

Lasseter

Xie

Arguello

et al. 2013

Neuropsychopharmacol

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“…The lack of changes in Fos expression in these regions does not exclude a role of AMPA receptors since AMPA signal transduction in these regions may involve molecular pathways that induce other IEGs, such as Arc or Zif268 that are also activated by drug-associated stimuli (Hearing et al, 2008;Koya et al, 2006;Schiltz et al, 2005;Thomas et al, 2003;Zavala et al, 2008). Collectively, the present findings suggest a region-specific involvement of AMPA receptors in cocaine-conditioned c-fos induction.…”

Section: Discussionmentioning

confidence: 62%

Region-specific involvement of AMPA/Kainate receptors in Fos protein expression induced by cocaine-conditioned cues

Zavala

Browning

Dickey

et al. 2008

European Neuropsychopharmacology

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This study investigated the effects of the AMPA/Kainate receptor antagonist, NBQX, on cueelicited cocaine-seeking behavior and concomitant changes in Fos protein expression. After cocaine self-administration training, rats underwent 24 days of abstinence during which they were exposed daily either to the self-administration environment with response-contingent cues previously paired with cocaine infusions available (Extinction group) or to an alternate environment (No Extinction group). Subsequently, rats were tested for cocaine-seeking behavior (i.e., operant responses without cocaine reinforcement) elicited by the cocaine-associated cues after pretreatment with either vehicle or NBQX (10 mg/kg, IP). NBQX markedly attenuated cueelicited cocaine-seeking behavior relative to vehicle pretreatment in the No Extinction group and also decreased cue-elicited Fos protein expression in a region-specific manner in the anterior cingulate and orbitofrontal cortices, basolateral amygdala, nucleus accumbens core, and dorsal caudate-putamen, suggesting involvement of AMPA glutamate systems in specific subregions of the neuronal circuitry activated by cocaine cues.

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“…Fos in PL neurons is also increased on the last day of cocaine self-administration (Zavala et al, 2007), the first day of extinction (when seeking levels were high) (Nic Dhonnchadha et al, 2012), and during cocaine-associated context discriminative or discrete cues that produced reinstatement (Ciccocioppo et al, 2001; Zhou et al, 2014). PL ARC mRNA is also elevated in cue-induced reinstatement (Zavala et al, 2008). After a period of cocaine abstinence, which has the impact of incubating, or upregulating craving for cocaine (Grimm et al, 2001), c-fos , zif268 , and ARC mRNA are all elevated in PL (Hearing et al, 2008).…”

Section: Dichotomous Functions For Dorsal (Pl) and Ventral (Il) Mpfc mentioning

confidence: 99%

Differential roles of medial prefrontal subregions in the regulation of drug seeking

et al. 2015

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The prefrontal cortex plays an important role in shaping cognition and behavior. Many studies have shown that medial prefrontal cortex (mPFC) plays a key role in seeking, extinction, and reinstatement of cocaine seeking in rodent models of relapse. Subregions of mPFC appear to play distinct roles in these behaviors, such that the prelimbic cortex (PL) is proposed to drive cocaine seeking and the infralimbic cortex (IL) is proposed to suppress cocaine seeking after extinction. This dichotomy of mPFC function may be a general attribute, as similar dorsal-ventral distinctions exist for expression vs. extinction of fear conditioning. However, other results indicate that the role of mPFC neurons in reward processing is more complex than a simple PL-seek vs. IL-extinguish dichotomy. Both PL and IL have been shown to drive and inhibit drug seeking (and other types of behaviors) depending on a range of factors including the behavioral context, the drug-history of the animal, and the type of drug investigated. This heterogeneity of findings may reflect multiple subcircuits within each of these PFC areas supporting unique functions. It may also reflect the fact that the mPFC plays a multifaceted role in shaping cognition and behavior, including those overlapping with cocaine seeking and extinction. Here we discuss research leading to the hypothesis that dorsal and ventral mPFC differentially control drug seeking and extinction. We also present recent results calling the absolute nature of a PL vs. IL dichotomy into question. Finally, we consider alternate functions for mPFC that correspond less to response execution and inhibition and instead incorporate the complex cognitive behavior for which the mPFC is broadly appreciated.

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Upregulation of Arc mRNA expression in the prefrontal cortex following cue‐induced reinstatement of extinguished cocaine‐seeking behavior

Cited by 62 publications

References 99 publications

Contribution of a Mesocorticolimbic Subcircuit to Drug Context-Induced Reinstatement of Cocaine-Seeking Behavior in Rats

Contribution of a Mesocorticolimbic Subcircuit to Drug Context-Induced Reinstatement of Cocaine-Seeking Behavior in Rats

Region-specific involvement of AMPA/Kainate receptors in Fos protein expression induced by cocaine-conditioned cues

Differential roles of medial prefrontal subregions in the regulation of drug seeking

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