Upregulation of Hsp90-beta and annexin A1 correlates with poor survival and lymphatic metastasis in lung cancer patients

Abstract

BackgroundHsp90-beta and annexin A1 were investigated as prognostic factors because of their apparent association with tumorigenesis. However, the effect of Hsp90-beta and annexin A1 in lung cancer remains poorly understood. The expressions of Hsp90-beta and annexin A1 in lung cancer and normal lung specimens were examined, and the relationships with respect to the clinico-pathological features and patient survival in lung cancer were analyzed.MethodsThe expression levels of Hsp90-beta and annexin A1 were examined using immunohistochemistry, in-situ hybridization, and Western blot.ResultsLung cancer tissues exhibited higher expression levels of Hsp90-beta and annexin A1 than the normal tissues (p < 0.05), and the expression levels of the markers were significantly associated with the pathological grade and lymphatic invasion of lung cancer (p < 0.05). Moreover, the upregulation of Hsp90-beta and annexin A1 correlated with decreased survival (p < 0.05).ConclusionThe upregulation of Hsp90-beta and annexin A1 were associated with poor post-surgical survival time and lymphatic metastasis of lung cancer patients. Moreover, the high expression of the markers was an independent predictor of poor outcomes.

Analysis of the Correlation between Expressions of HSP90&alpha;, HSP90&beta;, and GRP94, and the Clinicopathologic Characteristics in Tissues of Non-Small Cell Lung Cancer Patients

“…reported similar results [27]. This suggests that the difference in the expression of HSP90 seems to be dependent on the type of tumor.…”

“…They reported that the results are significant [27] and Lee et al reported that there was no significant difference in tumor size, lymph node metastasis, and stages in small cell lung cancer [26]. In this study, although there is a difference in the histological type of lung cancer, the results are similar to those of Lee et al However, it is considered that many studies should be performed on histologic types of lung cancer.…”

Impact of Annexin A3 expression in gastric cancer cells

“…Annexins are classified into subgroups A (in mammalians), B (in invertebrates), C (in fungi and some groups of unicellular eukaryotes), D (in plants), and E (in protists) [23]. It has been shown that disorders of Annexin expression are indirectly linked to different human diseases, such as rheumatoid arthritis, lung cancer, and diabetes [24][25]. The expression level of Annexin is closely related to the proliferation, differentiation, and invasion/migration of tumors as well as the clinical stages of tumors [12,20], and therefore has recently become a hot spot in the tumor research field.…”

Downregulation of Annexin A1 is correlated with radioresistance in nasopharyngeal carcinoma

“…The research evidence indicated that ANXA1 may specifically function as either a tumor suppressor or an oncogene candidate for certain cancers depending on the particular type of tumor cells/tissues (9). The upregulation of ANXA1 has been cor related with the development of hepatocellular carcinoma, colorectal cancer, lung cancer, pancreatic cancer, melanoma, skin cancer and endometrial carcinoma (21)(22)(23)(24)(25)(26)(27). Furthermore, its downregulation, as well as the translocation of ANXA1, has been shown to be a positive indicator for the development, progression and metastasis of prostate cancer, esophageal cancer, oral carcinoma, cervical cancer, intestinal-type sinonasal adenocarcinoma and NPC (17)(18)(19)28,29).…”