Upregulation of FGF9 and NOVA1 in cancer‐associated fibroblasts promotes cell proliferation, invasion and migration of triple negative breast cancer
Bo Zhang,
Yang Liu,
Jinsong Yu
et al.
Abstract:Cancer‐associated fibroblasts (CAFs) play a pivotal role in cancer progression. This study aimed to explore the roles of CAFs‐derived Fibroblast growth factor 9 (FGF9) and Neuro‐oncological ventral antigen 1 (NOVA1) in triple negative breast cancer (TNBC) progression. MDA‐MB‐231 and BT‐549 cells were cocultured with CAF conditioned‐medium (CAF‐CM) or normal fibroblasts conditioned‐medium (NF‐CM). MTT, EdU, colony formation, wound healing, transwell migration, and invasion assays were employed to determine cell… Show more
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