Upregulation of endogenous antioxidants and phase 2 enzymes by the red wine polyphenol, resveratrol in cultured aortic smooth muscle cells leads to cytoprotection against oxidative and electrophilic stress

Li, Yunbo; Cao, Zhixing; Zhu, Hong

doi:10.1016/j.phrs.2005.08.002

Cited by 205 publications

(124 citation statements)

References 43 publications

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“…These properties are mediated by its capability to scavenge free radicals and to enhance the activities of antioxidant enzymes including SOD and CAT (Losa, 2003;Li et al, 2006). In normal bone marrow cells of mice, pretreatment with 100 mg/kg resveratrol (9) before 3 Gy whole-body γ-radiation resulted in significant reduction of the mean total chromosome aberration frequency per metaphase, compared with the radiation-only group, which supported the radioprotective effects of resveratrol (9) in vivo.…”

Section: Resveratrolmentioning

confidence: 71%

Phenylpropanoids in radioregulation: double edged sword

2011

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Radiotherapy, frequently used for treatment of solid tumors, carries two main obstacles including acquired radioresistance in cancer cells during radiotherapy and normal tissue injury. Phenylpropanoids, which are naturally occurring phytochemicals found in plants, have been identified as potential radiotherapeutic agents due to their anti-cancer activity and relatively safe levels of cytotoxicity. Various studies have proposed that these compounds could not only sensitize cancer cells to radiation resulting in inhibition of growth and cell death but also protect normal cells against radiation-induced damage. This review is intended to provide an overview of recent investigations on the usage of phenylpropanoids in combination with radiotherapy in cancer treatment.

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Section: Resveratrolmentioning

confidence: 71%

Phenylpropanoids in radioregulation: double edged sword

2011

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“…17) BV-2 cells grown under various experimental conditions were washed twice with PBS, scraped off and collected into Eppendorf tube. Cells were lysed in ice-cold PBS by sonication and centrifuged at 15000×g for 5 min at 4°C.…”

Section: Measurement Of Reduced Glutathione (Gsh)mentioning

confidence: 99%

Protective Effects of Curcumin on Manganese-Induced BV-2 Microglial Cell Death

Park

Chun

2017

Biological & Pharmaceutical Bulletin

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Curcumin, a bioactive component in tumeric, has been shown to exert antioxidant, anti-inflammatory, anticarcinogenic, hepatoprotective, and neuroprotective effects, but the effects of curcumin against manganese (Mn)-mediated neurotoxicity have not been studied. This study examined the protective effects of curcumin on Mn-induced cytotoxicity in BV-2 microglial cells. Curcumin (0.1-10 µM) dose-dependently prevented Mn (250 µM)-induced cell death. Mn-induced mitochondria-related apoptotic characteristics, such as caspase-3 and -9 activation, cytochrome c release, Bax increase, and Bcl-2 decrease, were significantly suppressed by curcumin. In addition, curcumin significantly increased intracellular glutathione (GSH) and moderately potentiated superoxide dismutase (SOD), both which were diminished by Mn treatment. Curcumin pretreatment effectively suppressed Mn-induced upregulation of malondialdehyde (MDA), total reactive oxygen species (ROS). Moreover, curcumin markedly inhibited the Mn-induced mitochondrial membrane potential (MMP) loss. Furthermore, curcumin was able to induce heme oxygenase (HO)-1 expression. Curcuminmediated inhibition of ROS, down-regulation of caspases, restoration of MMP, and recovery of cell viability were partially reversed by HO-1 inhibitor (SnPP). These results suggest the first evidence that curcumin can prevent Mn-induced microglial cell death through the induction of HO-1 and regulation of oxidative stress, mitochondrial dysfunction, and apoptotic events.

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“…Treatment with RS has been found to reduce the oxidative stress and prevent various diseases by increasing the activities of several anti-oxidant enzymes including superoxide dismutase, catalase, glutathione, glutathione reductase, glutathione peroxidase and glutathione-S-transferase in rat aortic smooth muscle cells Li et al, 2006). RS has been demonstrated to maintain levels of glutathione in oxidatively stressed human peripheral blood mononuclear cells, and to elevate glutathione levels in human lymphocytes activated by hydrogen peroxide (Losa, 2003;Olas et al, 2004).…”

Section: Modulation Of Anti-oxidant Enzymes By Rsmentioning

confidence: 99%

Anti-atherogenic effects of resveratrol

Ramprasath

Jones

2010

Eur J Clin Nutr

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Resveratrol (RS), a polyphenol compound found in grapes and grape products, including wine, peanuts and berries, exists in cis-and trans-isomeric forms. RS is believed to decrease circulating low-density lipoprotein cholesterol levels and reduce cardiovascular disease (CVD) risk. However, it is possible that RS has other mechanisms to reduce the risk of CVD without altering lipid levels. The objective of this review is to critically examine results from recent research concerning potential effects of RS on CVD. RS exerts several health benefits including anti-atherogenic, anti-inflammatory and anti-cancer effects. RS may also prevent lipid oxidation, platelet aggregation, arterial vasodilation and modulates the levels of lipids and lipoproteins. As a potent, anti-oxidant RS reduces oxidative stress and regenerates a-tocopherol, which further strengthens the anti-oxidant defense mechanism. RS has been considered safe as no significant toxic effects have been identified, even when consumed at higher concentrations. This evidence identified RS as an effective anti-atherogenic agent, which could be used in the prevention and treatment of CVD.

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Upregulation of endogenous antioxidants and phase 2 enzymes by the red wine polyphenol, resveratrol in cultured aortic smooth muscle cells leads to cytoprotection against oxidative and electrophilic stress

Cited by 205 publications

References 43 publications

Phenylpropanoids in radioregulation: double edged sword

Phenylpropanoids in radioregulation: double edged sword

Protective Effects of Curcumin on Manganese-Induced BV-2 Microglial Cell Death

Anti-atherogenic effects of resveratrol

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