Upregulated miR‑20a‑5p expression promotes proliferation and invasion of head and neck squamous cell carcinoma cells by targeting of TNFRSF21

Wu, Hong; Pang, Pai; Liu, Minda; Wang, Song; Jin, Shan; Liu, Fa‐Yu; Sun, Changfu

doi:10.3892/or.2018.6477

Cited by 17 publications

(16 citation statements)

References 34 publications

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“…Zong et al 63 found that the overexpression of SDC3 can significantly inhibit the proliferation and metastasis of mesenchymal tumor cells. Wu et al 64 found that miR20a-5p promotes the proliferation, migration, and invasion of head and neck squamous cell carcinoma by down-regulating TNFRSF21. Another study found that TNFRSF21 also plays an important role in regulating leukocyte infiltration 65 .…”

Section: Discussionmentioning

confidence: 99%

Development of a novel immune-related genes prognostic signature for osteosarcoma

Deng

Zhang

et al. 2020

Sci Rep

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Immune-related genes (IRGs) are responsible for osteosarcoma (OS) initiation and development. We aimed to develop an optimal IRGs-based signature to assess of OS prognosis. Sample gene expression profiles and clinical information were downloaded from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) and Genotype-Tissue Expression (GTEx) databases. IRGs were obtained from the ImmPort database. R software was used to screen differentially expressed IRGs (DEIRGs) and functional correlation analysis. DEIRGs were analyzed by univariate Cox regression and iterative LASSO Cox regression analysis to develop an optimal prognostic signature, and the signature was further verified by independent cohort (GSE39055) and clinical correlation analysis. The analyses yielded 604 DEIRGs and 10 hub IRGs. A prognostic signature consisting of 13 IRGs was constructed, which strikingly correlated with OS overall survival and distant metastasis (p < 0.05, p < 0.01), and clinical subgroup showed that the signature’s prognostic ability was independent of clinicopathological factors. Univariate and multivariate Cox regression analyses also supported its prognostic value. In conclusion, we developed an IRGs signature that is a prognostic indicator in OS patients, and the signature might serve as potential prognostic indicator to identify outcome of OS and facilitate personalized management of the high-risk patients.

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Section: Discussionmentioning

confidence: 99%

Development of a novel immune-related genes prognostic signature for osteosarcoma

Deng

Zhang

et al. 2020

Sci Rep

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“…MiR-145-5p was reported to inhibit the proliferation of rat mesangial cells (RMCs) and vascular smooth muscle cells (VSMCs) by targeting different genes [49,50]. Protein phosphatase 3 catalytic subunit alpha is encoded by PPP3CA, and Ding et al [51] found that overexpressing hsa-miR-145-5p significantly reduced the mRNA expression of PPP3CA, which likely affected the cell cycle and invasion of the laryngeal squamous cell carcinoma (LSCC) cell line Tu-177.…”

Section: Discussionmentioning

confidence: 99%

An integrated analysis of the circRNA–miRNA–mRNA network reveals novel insights into potential mechanisms of cell proliferation during liver regeneration

Wang

Guo

Cheng

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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“… 46 Wu et al 2018 studied Upregulated miR-20a-5p expression in HNSCC cells and observed downregulation of TNFRSF21 expression. 47 …”

Section: Apoptotic Genes and Its Molecular Biologymentioning

confidence: 99%

Apoptosis and genes involved in oral cancer - a comprehensive review

et al. 2020

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Oral cancers needs relentless research due to high mortality and morbidity associated with it. Despite of the comparable ease in accessibility to these sites, more than 2/3rd cases are diagnosed in advanced stages. Molecular/genetic studies augment clinical assessment, classification and prediction of malignant potential of oral lesions, thereby reducing its incidence and increasing the scope for early diagnosis and treatment of oral cancers. Herein we aim to review the role of apoptosis and genes associated with it in oral cancer development in order to aid in early diagnosis, prediction of malignant potential and evaluation of possible treatment targets in oral cancer. An internet-based search was done with key words apoptosis, genes, mutations, targets and analysis to extract 72 articles after considering inclusion and exclusion criteria. The knowledge of genetics and genomics of oral cancer is of utmost need in order to stop the rising prevalence of oral cancer. Translational approach and interventions at the early stage of oral cancer, targeted destruction of cancerous cells by silencing or promoting involved genes should be the ideal intervention.

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Upregulated miR‑20a‑5p expression promotes proliferation and invasion of head and neck squamous cell carcinoma cells by targeting of TNFRSF21

Cited by 17 publications

References 34 publications

Development of a novel immune-related genes prognostic signature for osteosarcoma

Development of a novel immune-related genes prognostic signature for osteosarcoma

An integrated analysis of the circRNA–miRNA–mRNA network reveals novel insights into potential mechanisms of cell proliferation during liver regeneration

Apoptosis and genes involved in oral cancer - a comprehensive review

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