Upregulated LOX-1 Receptor: Key Player of the Pathogenesis of Atherosclerosis

Singh, Sanjiv; Gautam, Avtar Singh

doi:10.1007/s11883-019-0801-y

Cited by 32 publications

(25 citation statements)

References 121 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…P. gingivalis was even found in human atheroma ( Fiehn et al, 2005 ; Mahendra et al, 2015 ) and cells from atherosclerotic lesions ( Njoroge et al, 1997 ; Olsen and Progulske-Fox, 2015 ). LOX-1 is widely known to play a vital role in atherosclerosis ( Singh and Gautam, 2019 ). This receptor has been proved to contribute to the formation of atherosclerotic lesions in the initiation of atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

LOX-1 Regulates P. gingivalis-Induced Monocyte Migration and Adhesion to Human Umbilical Vein Endothelial Cells

Liu

et al. 2020

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Porphyromonas gingivalis (P. gingivalis) is one of the main periodontal bacteria. This pathogen was reported to enhance monocyte migration and adhesion to endothelial cells in atherosclerosis. The scavenger receptor lectin-like oxidized lowdensity lipoprotein receptor-1 (LOX-1) plays a pivotal role in atherogenesis. The aim of this study was to investigate whether LOX-1 modulates P. gingivalis-mediated monocyte migration and adhesion to endothelial cells and how it works. The results showed that the migration and adhesion of monocytic THP-1 cells to human umbilical vein endothelial cells (HUVECs) were significantly enhanced when HUVECs or THP-1 cells were challenged with P. gingivalis. Meanwhile, the expression level of LOX-1 in both HUVECs and THP-1 cells were also significantly increased by P. gingivalis stimulation. It is well known that ligand/receptor pairs monocyte chemoattractant protein-1 (MCP-1)/CC chemokine receptor 2 (CCR2), selectins/Integrins, and cell adhesion molecules (CAMs)/Integrins mediate monocyte migration and adhesion to endothelial cells. In this study, LOX-1 was demonstrated to be crucially involved in P. gingivalis-induced THP-1 cell migration and adhesion to HUVECs, by regulating expression of ligands MCP-1, intercellular adhesion molecule-1 (ICAM-1) and E-selectin in HUVECs and that of their receptors CCR2 and Integrin αMβ2 in THP-1 cells. The nuclear factor-kappa B (NF-κB) signaling pathway was proved to be involved in this process. In conclusion, LOX-1 plays a crucial role in P. gingivalis-induced monocyte migration and adhesion to endothelial cells. This result implies LOX-1 may act as a bridge in linking periodontitis to atherosclerosis.

show abstract

Section: Discussionmentioning

confidence: 99%

LOX-1 Regulates P. gingivalis-Induced Monocyte Migration and Adhesion to Human Umbilical Vein Endothelial Cells

Liu

et al. 2020

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

“…[60][61][62][63] in cycle of ligand-receptor interaction (oxLDL with its cognate receptor LOX-1). [65,66] So, intracellular cholesterol homeostasis by a plasma membrane port is the premier site or checkpoint for the regulation of atherosclerotic gust. Scavenger receptor class B type-1 (SR-B1) is a multiligand plasma membrane-bound receptor [67] that functions as a physiologically relevant HDL receptor to mediate the selective delivery of HDLcholesterol to cells (reverse cholesterol transport pathway).…”

Section: Intracellular Cholesterol Homeostasis By Plasma Membrane Tmentioning

confidence: 99%

“…Spontaneous oxidation of this deposited LDL will promote the accumulation of oxidized LDL (oxLDL), which, in turn, will boost the assignment of proinflammatory molecules through a vicious signaling cycle of ligand‐receptor interaction (oxLDL with its cognate receptor LOX‐1). [ 65,66 ] So, intracellular cholesterol homeostasis by a plasma membrane port is the premier site or checkpoint for the regulation of atherosclerotic gust.…”

Section: Intracellular Cholesterol Homeostasis By Plasma Membrane Tramentioning

confidence: 99%

Atherosclerosis and carcinoma: Two facets of dysfunctional cholesterol homeostasis

Chandra

2020

J Biochem & Molecular Tox

View full text Add to dashboard Cite

Although cholesterol is an essential and necessary component for biological systems; inappropriate accumulation of cholesterol in blood vessels and intracellular territory is also detrimental to living things. On one hand, cholesterol is the acting precursor of many metabolic regulators, a component of the structural veracity and scaffold fluidity of biomembranes, an insulator of electrical transmission in nerves and many more; on the other hand, its deposition in blood vessels induces atherosclerotic plaque and cardiovascular complications with the consequences of heart attack and stroke. It is also an emerging fact that cholesterol is a prelate in the cell nucleus for cell proliferation and any oddity in this venture may be the cause of tumorigenesis. Hence, cholesterol homeostasis is a very crucial element in issues of health management. Cholesterol is now a global target for maintaining quality health, particularly to control the two giants of the present world health tragedy: atherosclerosis and carcinoma, which appear to be the two facets of dysfunctional cholesterol homeostasis.

show abstract

“…Lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1), a type II integrin membrane glycoprotein receptor, is an acute-phase reactant, usually with low basal expression levels in the cells. Its expression increases rapidly due to various prooxidation and proinflammatory cytokines [ 5 , 6 ]. Therefore, it plays an important role in oxidative stress and cell damage induced by inflammatory factors.…”

Section: Introductionmentioning

confidence: 99%

sLOX-1: A Molecule for Evaluating the Prognosis of Recurrent Ischemic Stroke

Zheng

Huang

et al. 2021

Neural Plasticity

View full text Add to dashboard Cite

Several clinical parameters and biomarkers have been proposed as prognostic markers for stroke. However, it has not been clarified whether the risk factors affecting the prognosis of patients with recurrent and first-ever stroke are similar. In this study, we aimed to explore the relationship between soluble lectin-like oxidized low-density lipoprotein receptor 1 (sLOX-1) levels and the prediction of the functional outcome in patients with recurrent and first-ever stroke. A total of 266 patients with recurrent and first-ever stroke, who underwent follow-up for 3 months, were included in this study. Plasma samples were collected within 24 h after onset. The results showed that biomarkers for the prognosis of patients with recurrent stroke were different from that of those with first-ever stroke. sLOX-1 levels were correlated with modified Rankin Scale scores of patients with recurrent stroke alone ( r = 0.3232 , p = 0.001 ). sLOX-1 levels were also associated with an increased risk of unfavorable outcomes in patients with recurrent stroke with an adjusted odds ratio of 1.489 (95% confidence interval, 1.204–1.842, p < 0.0001 ). Combining the risk factors showed greater accuracy for prognosis, yielding a sensitivity of 93.2% and a specificity of 75%, with an area under the curve of 0.916, evaluated by the receiver operating characteristic curve. These findings suggest that the diagnosis and prognosis are different between patients with recurrent stroke and those with first-ever stroke, and sLOX-1 level is an independent prognostic marker in patients with recurrent stroke.

show abstract

Upregulated LOX-1 Receptor: Key Player of the Pathogenesis of Atherosclerosis

Cited by 32 publications

References 121 publications

LOX-1 Regulates P. gingivalis-Induced Monocyte Migration and Adhesion to Human Umbilical Vein Endothelial Cells

LOX-1 Regulates P. gingivalis-Induced Monocyte Migration and Adhesion to Human Umbilical Vein Endothelial Cells

Atherosclerosis and carcinoma: Two facets of dysfunctional cholesterol homeostasis

sLOX-1: A Molecule for Evaluating the Prognosis of Recurrent Ischemic Stroke

Contact Info

Product

Resources

About