Upregulated expression of kappa light chain by Epstein–Barr virus encoded latent membrane protein 1 in nasopharyngeal carcinoma cells via NF-κB and AP-1 pathways

Liu, Haidan; Zheng, Hou-Feng; Li, Ming; Hu, Duosha; Tang, Min; Cao, Yang

doi:10.1016/j.cellsig.2006.07.012

Cited by 40 publications

(52 citation statements)

References 43 publications

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“…Our previous studies provided evidence of sIg secretion by cancer cells. 5 Conversely, cancerous Ig and normal Ig are quite different with respect to genetic processing, 1,5 transcription, 6 expression level, 5 protein structure, 7 post-translational modification 7 and biological function 1, [8][9][10][11] (Table 1). Most of the cancerous Ig is aberrant or abnormal.…”

Section: Introductionmentioning

confidence: 99%

Heterogeneity of aberrant immunoglobulin expression in cancer cells

Zhi

et al. 2011

Cell Mol Immunol

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Accumulating evidence has shown that immunoglobulin (Ig) is 'unexpectedly' expressed by epithelial cancer cells and that it can promote tumor growth. The main purpose of this study was to explore the components of the cancerous Ig and its possible function. The presence of cancerous Ig in the Golgi apparatus was confirmed by immunofluorescence, indirectly suggesting that the cancerous Ig was processed and packaged in cancer cells. Western blot analysis and ELISA results indicated that cancer cells produced membrane Ig and secreted Ig into the supernatant fraction. The cancerous Ig consists of an a heavy chain and a k light chain. Finally, by analyzing the Ig components pulled down by protein A beads, the cancerous Ig was found to be structurally distinct from normal Ig. The cancerous Ig was truncated or aberrant. Although the underlying mechanism that causes the abnormalities has not been determined, our current discoveries strengthen our previous findings and promise fruitful future explorations.

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Section: Introductionmentioning

confidence: 99%

Heterogeneity of aberrant immunoglobulin expression in cancer cells

Zhi

et al. 2011

Cell Mol Immunol

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“…Since other virus-encoded oncoproteins, such as HBX, E6, E7, can also activate many signal pathways including NF-κB, AP-1 and ERK pathways (50)(51)(52), these oncoproteins might induce Ig gene expression through the mechanism similar to EBV-LMP1. All these give us new insight into this abnormal phenomenon, which lays foundations for further studies, as well as new strategies for cancer therapy.…”

Section: Some Regulatory Mechanisms Of Ig Expressed In Cancer Cellsmentioning

confidence: 99%

Immunoglobulin Expression and Its Biological Significance in Cancer Cells

Zheng

Liu

et al. 2008

Cell Mol Immunol

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“…Our previous studies demonstrated that the NF-kB signaling pathway is more active in LMP1-positive cancer cells. 7 However, when stimulated by TNF-a, we did not observe more abundant AID expression in LMP1-positive NPC cells. Additionally, the expression pattern of AID is not different between EBV-negative and EBV-positive gastric cancer cells (data not shown).…”

Section: Discussionmentioning

confidence: 66%

“…1 This innovative discovery suggested the possibility of Ig expression in cancer cells and several research groups categorically confirmed abnormal expression and secretion of Igs in non-lymphoid cancer cells. 2,3 Scientific researchers have demonstrated the biological functions [4][5][6] and the molecular mechanisms of Ig expression in cancer, [7][8][9][10] including the basis of V(D)J recombination. 11,12 However, whether Ig genes undergo class switching has not been determined and the mechanisms underlying cancer cell initiation of CSR are still unknown.…”

Section: Introductionmentioning

confidence: 99%

AID expression increased by TNF-α is associated with class switch recombination of Igα gene in cancers

et al. 2015

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Recently, immunoglobulins (Igs) were unexpectedly found to be expressed in epithelial cancers. Immunoglobulin class switching or class switch recombination (CSR) is a natural biological process that alters a B cell's production of antibodies (immunoglobulins) from one class to another. However, the mechanism of CSR of Ig genes in cancer is still unknown. Here, we confirmed by detecting the hallmark of CSR that the Iga gene in cancer underwent CSR. Then we focused on activation-induced cytidine deaminase (AID), a crucial factor for initiating CSR. Further studies using tumor necrosis factor (TNF)-a stimulation and specific inhibitor of NF-kB revealed that TNF-a could increase AID expression through NF-kB signaling. Finally, we demonstrated that AID could co-localize with protein kinase A and bind to the switching (Sa) region of the Iga gene. Overexpression of AID obviously enhanced Iga heavy chain expression and its binding ability to the Sa region. These findings indicated that TNF-a-induced AID expression is involved with CSR in cancer. Cellular & Molecular Immunology

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Upregulated expression of kappa light chain by Epstein–Barr virus encoded latent membrane protein 1 in nasopharyngeal carcinoma cells via NF-κB and AP-1 pathways

Cited by 40 publications

References 43 publications

Heterogeneity of aberrant immunoglobulin expression in cancer cells

Heterogeneity of aberrant immunoglobulin expression in cancer cells

Immunoglobulin Expression and Its Biological Significance in Cancer Cells

AID expression increased by TNF-α is associated with class switch recombination of Igα gene in cancers

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