Upregulated cholesterol biosynthesis facilitates the survival of methylation-retaining AML cells following decitabine treatment
Danielle R Bond,
Sean M Burnard,
Kumar Uddipto
et al.
Abstract:DNA hypomethylating agents (HMAs) are used to treat acute myeloid leukaemia (AML) and myelodysplasia patients who are unsuitable for intensive chemotherapy, but low response rates and therapy-resistant relapse remain significant challenges. To optimise HMA efficacy, we must understand how resistance and relapse arise from cells that survive treatment. Here we combine single-cell multi-omic analysis with parallel colony-forming assays to link HMA-induced molecular heterogeneity with functional consequences in A… Show more
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