Upper vaginectomy for in situ and occult, superficially invasive carcinoma of the vagina

Treatment of Vaginal Intraepithelial Neoplasia with Laser Ablation and Upper Vaginectomy

“…In the report by Rome and England [9], the overall cure rate for the excisional treatment of high-grade VAIN was 69%. In another study, Hoffman et al [10] have demonstrated a cure rate of 83% with upper vaginectomy.…”

“…By analyzing the results of our study, we can see Diakomanolis/Rodolakis/Boulgaris/ Blachos/Michalas that VAIN in the upper vagina of women who have undergone hysterectomy should be excised along with the vaginal cuff scar. Surgical excision is important for highgrade lesions involving the vault scar because of the possibility of VAIN being embedded in the scar as inclusion cysts or crypts, as reported by Hoffman et al [10].…”

Risk factors for recurrence of vaginal intraepithelial neoplasia in the vaginal vault after laser vaporization

“…Some reports have suggested that laser vaporization may not be needed in these lesions because VAIN I often regress [23]. Nevertheless, we tend to treat VAIN I in our institute because VAIN I is considered as a potential risk factor for VAIN II or higher lesions [24]; secondly, high-risk HPV infection was not a independent risk factor for disease recurrence.…”

Primary vaginal cancer: role of MRI in diagnosis, staging and treatment

“…1,[16][17][18][19] There is an increasing trend towards organ preservation and treatment strategies based on combined external beam radiation and brachytherapy, often with concurrent chemotherapy, 14,20,21 surgery being reserved for those with in situ or very early-stage disease. 22 Increasing utilization of MR may provide superior delineation of tumour volume, both for initial staging and follow-up, to allow for better treatment planning. 23 …”