Upper respiratory tract infections evaluation of prescriptions

Özdemir, Serdar; Öztürk, Tuba Cimilli; Metiner, Yasin; Ak, Rohat; Öcal, Oktay

doi:10.14744/nci.2015.69885

Cited by 4 publications

(1 citation statement)

References 16 publications

(14 reference statements)

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“…National guidelines (NICE 2013) also recommend home management of fever with associated discomfort or pain with antipyretics and analgesics like Paracetamol and Ibuprofen. Both have similar safety and tolerability but globally paracetamol is considered as having better gastrointestinal, renal and respiratory safety and overall better tolerability than Ibuprofen (8)(9)(10) .…”

Section: Introductionmentioning

confidence: 99%

Evaluating the Role of Paracetamol in Alleviating Symptoms of Upper Respiratory Infections

Kalsoom¹,

Bibi²,

Saif³

et al. 2023

PJMHS

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Background: Fever is a very common adaptive immune response in acute respiratory tract disorders during infancy. Antipyretic / analgesic drugs such as paracetamol (acetaminophen) are widely used to improve the comfort of the child. Objective: To determine the efficacy of paracetamol in symptomatic relief of upper respiratory tract infections in children aged 2 to 5 years. Study Design: Descriptive case series Study Setting: Department of Pediatrics, Ayub Teaching Hospital, Abbottabad Duration of study: Six months from October 13, 2020, to April 13, 2021 Subjects and methods: All children aged 2 to 5 years of either gender having upper respiratory tract infections and duration of symptoms of >2 days were consecutively enrolled. Patients were prescribed Paracetamol in a dose of 10 mg/kg/dose 6 hourly for 3 days. Patients were followed up after 3 days to see the efficacy of Paracetamol in symptomatic relief of upper respiratory tract infections. Results: Of 284 children, the mean age of the children was 4.01 ±1.10 years. There were 135 (47.5%) males and 149 (52.5%) females. The mean weight of the children was 12.36 ±3.42 kg. The mean duration of symptoms was 5.11 ±0.95 days. The efficacy of paracetamol in symptomatic relief of upper respiratory tract infection was found to be 184 (64.8%). A non-significant difference of efficacy of paracetamol was observed with age (p-value 0.578), gender (p-value 0.908), weight (pvalue 0.586), and duration of symptoms (p-value 0.872). Practical Implication: This study was planned to determine the efficacy of paracetamol in symptomatic relief of upper respiratory tract infections. The results of this study could be used in owing to locally produced evidence. Conclusion: The efficacy of paracetamol was observed in 64.8% children aged 2 to 5 years with symptomatic relief of upper respiratory tract infections in children. Keywords: Efficacy, Paracetamol, Children, Upper Respiratory Tract Infections

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Section: Introductionmentioning

confidence: 99%

Evaluating the Role of Paracetamol in Alleviating Symptoms of Upper Respiratory Infections

Kalsoom¹,

Bibi²,

Saif³

et al. 2023

PJMHS

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Modulation of transient receptor potential (TRP) channels by plant derived substances used in over-the-counter cough and cold remedies

2023

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Background Upper respiratory tract infections (URTIs) impact all age groups and have a significant economic and social burden on society, worldwide. Most URTIs are mild and self-limiting, but due to the wide range of possible causative agents, including Rhinovirus (hRV), Adenovirus, Respiratory Syncytial Virus (RSV), Coronavirus and Influenza, there is no single and effective treatment. Over-the-counter (OTC) remedies, including traditional medicines and those containing plant derived substances, help to alleviate symptoms including inflammation, pain, fever and cough. Purpose This systematic review focuses on the role of the major plant derived substances in several OTC remedies used to treat cold symptoms, with a particular focus on the transient receptor potential (TRP) channels involved in pain and cough. Methods Literature searches were done using Pubmed and Web of Science, with no date limitations, using the principles of the PRISMA statement. The search terms used were ‘TRP channel AND plant compound’, ‘cough AND plant compound’, ‘cough AND TRP channels AND plant compound’, ‘cough AND P2X3 AND plant compound’ and ‘P2X3 AND plant compound’ where plant compound represents menthol or camphor or eucalyptus or turpentine or thymol. Results The literature reviewed showed that menthol activates TRPM8 and may inhibit respiratory reflexes reducing irritation and cough. Menthol has a bimodal action on TRPA1, but inhibition may have an analgesic effect. Eucalyptus also activates TRPM8 and inhibits TRPA1 whilst down regulating P2X3, aiding in the reduction of cough, pain and airway irritation. Camphor inhibits TRPA1 and the activation of TRPM8 may add to the effects of menthol. Activation of TRPV1 by camphor, may also have an analgesic effect. Conclusions The literature suggests that these plant derived substances have multifaceted actions and can interact with the TRP ‘cough’ receptors. The plant derived substances used in cough and cold medicines have the potential to target multiple symptoms experienced during a cold.

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A prospective, post-marketing surveillance (PMS) study to monitor the safety of fixed dose combination of Triprolidine Hydrochloride IP 2.5 mg and Phenylephrine Hydrochloride IP 5 mg [Recofast Tablets] for the symptomatic relief in patients with upper respiratory tract infections

Kadoo¹,

Patil²

2023

IJPP

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Upper Respiratory Tract Infection (URTI) is the most frequent illness in humans. The vast majority of acute upper respiratory tract infections are caused by viruses. These cause a variety of patient diseases including acute bronchitis, common cold, influenza, and respiratory distress syndromes.The study was conducted in patients with upper respiratory tract infections to see if the medication provides symptomatic relief in these conditions. Other conditions like allergic rhinitis and influenza were also included in the study for symptomatic relief.This is an open label, multicentric, active Post Marketing Surveillance (PMS) study with an objective to assess safety of fixed dose combination regarding Recofast tablets (Triprolidine Hydrochloride IP 2.5 mg and Phenylephrine Hydrochloride IP 5 mg) which was evaluated in 150 participants from different geographical regions. And then results were documented. A total of 19 (13%) patients recorded minor adverse event from these regions. Out of 150 patients 95 were male & 55 were female. All the patients were in the range of 18-80 years.No significant adverse events were observed during the course of the study, only 13% patients recorded minor adverse events from all regions. Thus this formulation is completely safe and effective in the management of Upper Respiratory Tract Infections and allergies.

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Upper respiratory tract infections evaluation of prescriptions

Cited by 4 publications

References 16 publications

Evaluating the Role of Paracetamol in Alleviating Symptoms of Upper Respiratory Infections

Evaluating the Role of Paracetamol in Alleviating Symptoms of Upper Respiratory Infections

Modulation of transient receptor potential (TRP) channels by plant derived substances used in over-the-counter cough and cold remedies

A prospective, post-marketing surveillance (PMS) study to monitor the safety of fixed dose combination of Triprolidine Hydrochloride IP 2.5 mg and Phenylephrine Hydrochloride IP 5 mg [Recofast Tablets] for the symptomatic relief in patients with upper respiratory tract infections

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