Rehabilitation with physical therapy exercises is important to maintain and regain desirable physical strength to patients who underwent surgery or suffer temporary physical impairments. This process generally requires the patient to perform exercises regularly and correctly with assistance from therapist at a rehabilitation clinic. But this approach results in costly, resource intensive and subjective assessments in managing physical therapy exercises. In order to alleviate these drawbacks, holistic physical therapy management system for tele-rehabilitation is proposed leveraging on multimodal sensor network, intelligent motion analysis, collaborative user interactions and communication framework. With employing proposed system in patients' home and rehabilitation clinic, exercises monitoring, assessment and interaction with multiple patients and a therapist can be established in convenient and cost-effective manners.