Upper limb musculoskeletal abnormalities and poor metabolic control in diabetes

Ramchurn, Navdha R.; Mashamba, Chiedza; Leitch, Elizabeth Mary; Arutchelvam, Vijayaraman; Narayanan, Kilimangalam; Weaver, Judith B.; Hamilton, Jennifer D.; Heycock, Carol; Saravanan, Vadivelu; Kelly, Clive

doi:10.1016/j.ejim.2009.08.001

Cited by 140 publications

(139 citation statements)

References 21 publications

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“…Compared to reports concerning diabetes-related musculoskeletal manifestations in adults, predominantly osteoporosis and increased fracture risk, upper limb musculoskeletal abnormalities (shoulder and hand), limited joint mobility, septic arthritis, carpal tunnel syndrome, trigger finger, and Dupuytren's contracture [7][8][9][10]13], we found a range of joint, …”

Section: Discussioncontrasting

confidence: 38%

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2016

DRTOA

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Section: Discussioncontrasting

confidence: 38%

“…Previous studies of DM in adults have identified limited joint mobility, stiff hand syndrome, diabetic muscular infarction, Page 2 of 8 and neuropathy, flexor tenosynovitis, and carpal tunnel syndrome as its predominant musculoskeletal manifestations [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Untitled

2016

DRTOA

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“…[38][39][40] This may be an underestimate because locomotor disease, which may also affect manual dexterity in those with upper limb involvement, was found to be present in 75% of patients with diabetes. 41 Furthermore, reduced manual dexterity was…”

Section: Discussionmentioning

confidence: 99%

Needle with a Novel Attachment Versus Conventional Screw-Thread Needles: A Preference and Usability Test Among Adults with Diabetes and Impaired Manual Dexterity

Hansen

Lilleøre²,

Ter-Borch³

2011

Diabetes Technology & Therapeutics

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Background: NovoTwist Ò (Novo Nordisk A/S, Bagsvaerd, Denmark) is an insulin pen needle that features a novel attachment and detachment system. The aim of this test was to assess overall preference and handling of NovoTwist compared with conventional screw-thread needles in people with type 1 or type 2 diabetes. Methods: One hundred twenty adults with type 1 or type 2 diabetes and manual dexterity dysfunction who were currently self-injecting with an insulin pen were included in this open-label, randomized, crossover test. Participants were stratified according to the impact that manual dexterity problems had on their ability to inject insulin (1 ¼ no effect at all; 4 ¼ a lot), and those rated as 1 were excluded from subanalyses because of low numbers. Following instruction, participants attached the needle to Next Generation FlexPen Ò (Novo Nordisk A/S), made an injection into a foam cushion, and detached the needle; this process was repeated three times with NovoTwist and the participant's current screw-thread needle (or NovoFine Ò [Novo Nordisk A/S]) in a random order. Responses to questions on user experience with each needle were subsequently recorded on a 6-point rating scale (1 ¼ very difficult; 6 ¼ very easy). Results: Significantly more respondents had a preference for NovoTwist (79%) compared with the conventional screw-thread needles (21%, P < 0.001). Significantly more respondents preferred NovoTwist for both ease of attachment (80%, P < 0.001) and ease of detachment (74%, P < 0.001). Most respondents found NovoTwist the most appropriate needle for performing everyday injections (71%, P < 0.001). Conclusions: Such preference by patients has a positive impact on the treatment of diabetes as NovoTwist may alleviate the burden of performing everyday injections through its ease of use.

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“…Insulin resistance in skeletal muscle is considered an early hallmark in the development of type 2 diabetes [2]. A long-term diabetic condition usually results in skeletal muscle myopathy, which is a common source of disability in both type 1 and 2 diabetic populations and is increasing in prevalence [3][4][5]. Despite accumulating studies, the molecular mechanism underlying the skeletal muscle defects in the diabetic condition remains limited.…”

Section: Introductionmentioning

confidence: 99%

O-GlcNAcase deficiency suppresses skeletal myogenesis and insulin sensitivity in mice through the modulation of mitochondrial homeostasis

et al. 2016

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Aims/hypothesis O-GlcNAcylation is implicated in modulating mitochondrial function, which is closely involved in regulating muscle metabolism. The presence of O-GlcNAcase (OGA), the enzyme involved in the removal of O-GlcNAc, in mitochondria was recently confirmed in rats. In the present study, we investigated the regulation of myogenesis and muscle insulin sensitivity to OGA in mice, with a focus on mitochondria. Methods C57BL/6J mice fed a high-fat diet for 4 months were used to observe mitochondrial density, activity and O-GlcNAcylation in muscle. Small interfering RNA and overexpression vectors were used to modulate protein content in vitro. Results High-fat feeding decreased the OGA level and largely increased mitochondrial O-GlcNAcylation in mouse skeletal muscle that was accompanied by decreased levels of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), decreased mitochondrial density and disrupted mitochondrial complex activities. Knockdown of OGA in C2C12 myoblasts promoted PGC-1α degradation, resulting in the suppression of mitochondrial biogenesis and myogenesis, whereas neither knockdown of O-GlcNAc transferase nor overexpression of OGA had significant effects on myogenesis. Mitochondrial dysfunction as evidenced by decreased ATP content and increased reactive oxygen species production, and increased lipid and protein oxidation was observed in both myoblasts and myotubes after OGA knockdown. Meanwhile, elevated O-GlcNAcylation through either OGA knockdown or treatment with the OGA inhibitor PUGNAc and the O-GlcNAc transferase substrate D-GlcNAc suppressed myotube insulin signalling transduction and glucose uptake. OGA overexpression had no significant effect on insulin sensitivity but sufficiently improved the insulin resistance induced by D-GlcNAc treatment. Conclusions/interpretation These data suggest that OGA can modulate mitochondrial density via PGC-1α and mitochondrial function via protein O-GlcNAcylation. In this manner, OGA appears to play a key role in myogenesis and the development of muscle insulin resistance.

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Upper limb musculoskeletal abnormalities and poor metabolic control in diabetes

Cited by 140 publications

References 21 publications

Untitled

Untitled

Needle with a Novel Attachment Versus Conventional Screw-Thread Needles: A Preference and Usability Test Among Adults with Diabetes and Impaired Manual Dexterity

O-GlcNAcase deficiency suppresses skeletal myogenesis and insulin sensitivity in mice through the modulation of mitochondrial homeostasis

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