Upper Gastrointestinal Tract Cancers as Double-cancers in Elderly Patients with Oral Squamous Cell Carcinoma

Ikawa, Hiroaki; Tonogi, Morio; Yamane, Gen-yuki; Yamauchi, Tomohiro; Tanaka, Yoïchi; Sato, Michio; Matsui, Junichi; Ando, Nobutoshi; Katakura, Akira

doi:10.2209/tdcpublication.53.9

Cited by 8 publications

(10 citation statements)

References 17 publications

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“…Reasons for exclusion of other studies are mentioned in Figure . Review of the 96 screening studies resulted in the selection of 23 Lugol chromoendoscopy screening studies (Table ) . Most other screening studies were performed with only white‐light endoscopy (eg, triple‐endoscopy) or with the use of PET/CT.…”

Section: Resultsmentioning

confidence: 99%

“…The combined quality score of the MINORS and relevance criteria qualified 15 studies as medium or high quality and these were included in the present review . The remaining studies of low quality were excluded.…”

Section: Resultsmentioning

confidence: 99%

“…The 3 studies with the highest prevalence included only or mostly patients with a hypopharyngeal index tumor . Two Japanese studies only included patients with oral cavity tumors . The average esophageal‐SPT prevalence of the 12 Asian studies was 17.7% (358 of 2627, 95% CI: 12.7‐22.7).…”

Section: Resultsmentioning

confidence: 99%

“…Nine Asian studies reported data of esophageal‐SPTs per sub‐location of the index HNSCC (Figure ) . The prevalence of esophageal‐SPTs was the highest in patients with hypopharyngeal index tumors, followed by patients with oropharyngeal, oral cavity, and laryngeal and nasopharyngeal tumors.…”

Section: Resultsmentioning

confidence: 99%

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Early detection of esophageal second primary tumors using Lugol chromoendoscopy in patients with head and neck cancer: A systematic review and meta‐analysis

et al. 2018

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Background Early detection of esophageal secondary primary tumors (SPTs) in head and neck squamous cell carcinoma (HNSCC) patients could increase patient survival. The purpose of this study was to determine the diagnostic yield of esophageal SPTs using Lugol chromoendoscopy. Methods A systematic review of all available databases was performed to find all Lugol chromoendoscopy screening studies. Results Fifteen studies with a total of 3386 patients were included. The average yield of esophageal‐SPTs in patients with HNSCC was 15%. The prevalence was the highest for patients with an index hypopharyngeal (28%) or oropharyngeal (14%) tumor. The esophageal‐SPTs were classified as high‐grade dysplasia in 49% of the cases and as invasive carcinoma's in 51%. Conclusion Our results show that 15% of the patients with HNSCC that underwent Lugol chromoendoscopy were diagnosed with an esophageal‐SPT. Based on these results there is enough evidence to perform Lugol chromoendoscopy, especially in an Asian patient population.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Early detection of esophageal second primary tumors using Lugol chromoendoscopy in patients with head and neck cancer: A systematic review and meta‐analysis

et al. 2018

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“…In addition, the quantity of patients presenting with two types of cancer, with oral cancer as the primary malignancy, is reportedly on the rise (12). …”

Section: Discussionmentioning

confidence: 99%

Squamous cell carcinoma of the tongue in a female with advanced breast cancer: A case report of an elderly patient presenting with two types of cancer

et al. 2014

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Elderly patients with cancer are frequently undertreated as they are considered to be unfit for treatment due to inaccurate estimations of the operative risk. In the current study, the case of an 81-year-old female smoker with advanced breast cancer is presented. The patient had received numerous cycles of chemo- and hormonal therapy and the cancer only progressed locally. After six years, the patient developed a second type of cancer; a moderately differentiated squamous cell carcinoma of the tongue. The patient refused any local treatment and she received supportive care only. There is currently a lack of data regarding the molecular mechanisms of second primary cancers as well as other delayed outcomes following cancer treatment. Therefore, it is proposed that chemotherapy may promote the presentation of the second cancer as a result of immunosuppression.

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Is There a Role for Triple Endoscopy in the Staging of Head and Neck Cancer?

Tsang

2019

Difficult Decisions in Surgery: An Evidence-Based Approach

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Upper Gastrointestinal Tract Cancers as Double-cancers in Elderly Patients with Oral Squamous Cell Carcinoma

Cited by 8 publications

References 17 publications

Early detection of esophageal second primary tumors using Lugol chromoendoscopy in patients with head and neck cancer: A systematic review and meta‐analysis

Early detection of esophageal second primary tumors using Lugol chromoendoscopy in patients with head and neck cancer: A systematic review and meta‐analysis

Squamous cell carcinoma of the tongue in a female with advanced breast cancer: A case report of an elderly patient presenting with two types of cancer

Is There a Role for Triple Endoscopy in the Staging of Head and Neck Cancer?

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