“… 33 , 34 , 37 , 40 Our analysis of data from Stefanolo et al. 61 showed no significant difference of the prevalence of GORD in CD in those less than 50 years of age (6.1% of 1140) compared to those older (8.5% of 188, p = 0.20), and age appeared to have no influence on the prevalence of GORD in CD based on 3 studies, 33 , 34 , 57 but a pooled statistical analysis was not possible. Two studies 53 , 54 yielded conflicting results regarding duodenal histology predicting GORD symptoms, with a larger study of 549 CD cases reporting mucosal integrity, denoted by villous height/crypt depth ratio, negatively correlating with GORD symptoms (r = −0.115, p = 0.0070).…”