Upper extremity subclinical autonomic and peripheral neuropathy in systemic lupus erythematosus

Fathalla, Mahmoud M; EL-Badawy, Mohja A.

doi:10.4103/1110-161x.157868

Cited by 5 publications

(3 citation statements)

References 37 publications

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“…This study did not show that frequency of subclinical PN in patients with SLE and the percentage of sympathetic nervous system affection was modest [four (13.3%) patients] in comparison with 40% in the study by Fathalla and El-Badawy [30]. The possible explanation is that the diagnosis of sympathetic neuropathy should be confirmed by the ACR nomenclature and case definitions for neuropsychiatric lupus syndromes after the screening by single diagnostic tool such as SSR.…”

Section: Discussioncontrasting

confidence: 64%

“…In contradiction to this result, Goh et al [26] stated that the subclinical PN is common in patients with SLE. Moreover, Fathalla and El-Badawy [30] investigated the association of subclinical autonomic and PN with SLE. Pure sensory, mixed sensory-motor abnormalities were detected in two patients.…”

Section: Discussionmentioning

confidence: 99%

“…SSR was not elicited in 13 of 43 patients, whereas latency and amplitude abnormalities were detected in 11 of 43 and 9 of 43 patients, respectively. The sympathetic nervous system was affected in up to 40% of patients with lupus according to the study by Fathalla and El-Badawy [30].…”

Section: Discussionmentioning

confidence: 99%

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Pattern of peripheral neuropathy in systemic lupus erythematosus: clinical, electrophysiological, and laboratory properties and their association with disease activity

Imam

Koriem

Hassan

et al. 2019

Egypt Rheumatol Rehabil

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To study clinical, electrophysiological, and laboratory properties of peripheral neuropathy (PN) in systemic lupus erythematosus (SLE) and their association with disease activity. Patients and methods A total of 30 patients who met the American College of Rheumatology case definition criteria for SLE-PN and 30 age-matched and sex-matched patients with SLE without PN were selected from the Main Alexandria University Hospital Physical Medicine, Rheumatology and Rehabilitation clinic. Demographic data, SLE-related clinical, laboratory data, Systemic Lupus Activity Measure (SLAM) index, and nerve conduction studies were done. This case-control study compared clinical and SLE-related features, laboratory, and SLAM index in patients with SLE with PN versus those without neuropathy. Results The results showed that the most common PN subtype was sensorimotor polyneuropathy which occurred in 18 (60%) patients; the most common PN pathology was axonal degeneration, which occurred 19 (63.3%) patients; and the most common associated nerve entrapment was carpal tunnel syndrome in 10 (33.3%) patients. In comparison between group I (SLE with PN) and group II (SLE without PN), there was no statistically significant difference between the two groups regarding demographic data, disease duration, and lupus clinical features, except malar rash and lupus nephritis, which showed significant increase in patients with SLE with PN compared with patients with SLE without PN (P=0.003 and P<0.001, respectively). There was no statistically significant difference among PN subtype groups regarding sex, age, and immunological markers. Regarding diseases activity, SLAM index showed a significant increase in patients with SLE with PN compared with patients with SLE without PN (P=0.006). Conclusion The pattern of neuropathy in SLE is mainly axonal. Moreover, the most common PN subtype is sensorimotor polyneuropathy. The study suggests significant association of PN in patients with SLE with nephritis, malar rash, and SLAM index.

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Section: Discussioncontrasting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

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Pattern of peripheral neuropathy in systemic lupus erythematosus: clinical, electrophysiological, and laboratory properties and their association with disease activity

Imam

Koriem

Hassan

et al. 2019

Egypt Rheumatol Rehabil

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Chronic inflammatory demyelinating polyradiculoneuropathy associated with systemic lupus erythematosus

Julio

Cortês

Costallat

et al. 2021

Seminars in Arthritis and Rheumatism

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Intravenous cyclophosphamide treatment for systemic lupus erythematosus with severe autonomic disorders confirmed by head-up tilt table test: A case series

Umeda

Kawano

Endo

et al. 2021

Modern Rheumatology Case Reports

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Autonomic disorders are common in patients with SLE, but the therapeutic strategy and methods for evaluating the effects of therapy have not been established. We describe the three cases of SLE patients who developed severe autonomic disorders as demonstrated by the head-up tilt table test (HUT). All three patients were treated by intensive immunosuppressive treatments including cyclophosphamide (IVCY); their HUT results all became negative. Our cases suggest that IVCY treatment can be a good therapeutic option for severe autonomic disorders in SLE patients. The HUT is a useful objective method for the diagnosis of and the evaluation of longitudinal therapeutic effects on autonomic disorders in SLE patients with orthostatic intolerance.

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Upper extremity subclinical autonomic and peripheral neuropathy in systemic lupus erythematosus

Cited by 5 publications

References 37 publications

Pattern of peripheral neuropathy in systemic lupus erythematosus: clinical, electrophysiological, and laboratory properties and their association with disease activity

Pattern of peripheral neuropathy in systemic lupus erythematosus: clinical, electrophysiological, and laboratory properties and their association with disease activity

Chronic inflammatory demyelinating polyradiculoneuropathy associated with systemic lupus erythematosus

Intravenous cyclophosphamide treatment for systemic lupus erythematosus with severe autonomic disorders confirmed by head-up tilt table test: A case series

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