“…Traditionally the patient's pain is managed with general anesthesia and narcotic medication for surgery, followed by oral medications, including acetaminophen, non-steroidal anti-inflammatory drugs (NSAIDs), opioid-containing oral analgesics (e.g., codeine-acetaminophen), or a combination of these along with intravenous pain medications (including patient-controlled analgesia), after surgery 9 . Despite the availability of these analgesic drugs, many patients still do not achieve effective pain control 10 , often times because adverse gastrointestinal, hemostatic, and renal effects that become prohibitive to achieving adequate analgesic concentrations.…”