Upper and lower bounds on oxygen transfer rates: A theoretical consideration

A theoretical analysis of nonsteady-state oxygen transfer in layers of hemoglobin solution

“…Thews (1957) applied an approximate solution of the diffusion equations based on simplifying assumptions to the data of Kreuzer (1950) and Klug et al (1956) and found good agreement of the values of the oxygen diffusion coefficient between his calculations and previous approaches where a comparison was possible. He neglected, however, the simultaneous diffusion of oxyhemoglobin, as did later studies by Marx et al (1960), Weissman and Mockros (1969), Dindorf et al (1971), and Mikic et al (1972). Moll (1968/69), using numerical methods, on the other hand evaluated the acceleration of oxygen uptake and release by oxyhemoglobin diffusion in red cells.…”