The existing interference assessment methods usually consider the special scenario of earth station coincidence. However, in practice, earth stations such as gate stations are sparsely distributed and often do not coincide. Aiming at the problem of how to efficiently calculate the co-frequency interference between Non-Geostationary Satellite Orbit (NGSO) systems with high complexity and a large amount of data, the influencing factors of interference scenes between NGSO systems with non-earth station coincidence are analyzed. The time-varying expression of the bit error rate (BER) of the interference evaluation index to measure the system performance is derived. An interference analysis method based on the beam coverage and link angle is proposed. In this method, four interference time-varying parameters are reduced to two. One of them is associated with the distance between earth stations, which is used to rapidly evaluate the probability of harmful interference between NGSO systems. It provides a reference for the construction of the spacing of earth stations.