UPLC-QTOF-MS based metabolomics coupled with the diagnostic ion exploration strategy for rapidly evaluating sulfur-fumigation caused holistic quality variation in medicinal herbs, Moutan Cortex as an example

Li, Xiuyang; Xu, Jin–Di; Xu, Jun; Kong, Ming; Zhou, Shanshan; Mao, Qian; Brand, Eric; Chen, Hubiao; Liu, Hong-quan; Li, Songlin

doi:10.1039/c5ay01404b

Cited by 17 publications

(13 citation statements)

References 38 publications

(36 reference statements)

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“…To monitor the sulfur-fumigation process of AB and dissect the chemical transformation mechanisms of the screened markers, five major active AB compounds (EC, BE, OA, FA, and 5-HF) were simultaneously determined at seven time points within 24 h, as well as four weight ratios of sulfur to herbal materials (blank, 1:20, 1:40, and 1:80) (Supplementary Table S3 ). Furthermore, PCA and PLS-DA analysis with SIMCA software were used to further evaluate the extent of the sulfur-fumigation ( Figure 5 ) ( Li et al, 2016 ; Kang et al, 2017 ). Overall, the quality of AB was significantly different before and after sulfur-fumigation.…”

Section: Resultsmentioning

confidence: 99%

Elucidation of Characteristic Sulfur-Fumigated Markers and Chemical Transformation Mechanism for Quality Control of Achyranthes bidentate Blume Using Metabolome and Sulfur Dioxide Residue Analysis

et al. 2018

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Achyranthes bidentata Blume (AB) is a health food and a sulfur-free herbal medicine that is one of the most heavily sulfur-fumigated herbs in the marketplace. In this work, a comprehensive approach using ultra-performance liquid chromatography coupled with quadrupole time-of-flight-MS (UPLC-Q-TOF-MS) and multivariate statistical analysis was developed to identify characteristic sulfur-fumigation markers, elucidate chemical transformation mechanisms and characterize the degree of sulfur-fumigation of AB. Non-fumigated and sulfur-fumigated AB samples were compared by UPLC-Q-TOF-MS/MS analysis. Three triterpene saponins (Betavulgarosides II–IV) and two amides (Feruloyl-4-O-methyldopamine and Moupinamide) were identified as characteristic markers, which were positively correlated with two active AB components, namely oleanic acid and ferulic acid, respectively. Moreover, the extent of the sulfur-fumigation under different weight ratios of sulfur to herbal materials (1:20, 1:40, and 1:80) was analyzed based on chemical transformations and sulfur dioxide residues. Further verification showed that the ratio of 1:40 within 1 h was reasonable and efficient for herb quality preservation and assurance. This study provides a reliable sulfur-fumigation protocol for the quality control of AB and other herbs.

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Section: Resultsmentioning

confidence: 99%

Elucidation of Characteristic Sulfur-Fumigated Markers and Chemical Transformation Mechanism for Quality Control of Achyranthes bidentate Blume Using Metabolome and Sulfur Dioxide Residue Analysis

et al. 2018

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“…LC-MS based metabolomics approaches are being successfully employed in many evaluations of the holistic quality of medicinal herbs. UPLC-QTOF-MS based metabolomics coupled with characteristic ion exploration, a novel and practical strategy was proposed for the rapid evaluation of holistic quality variations caused by the sulfur-fumigation of CM [ 137 ]. The results suggested that sulfur-fumigation could significantly affect the holistic quality of CM by chemically transforming pinane monoterpene glucosides, the main bioactive components of CM, to their corresponding sulfonate derivatives.…”

Section: Analytical Methods For Quality Evaluation Of CMmentioning

confidence: 99%

Origins, Phytochemistry, Pharmacology, Analytical Methods and Safety of Cortex Moutan (Paeonia suffruticosa Andrew): A Systematic Review

Wang

Peng

et al. 2017

Molecules

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Cortex Moutan (CM), a well-known traditional Chinese medicine, is commonly used for treating various diseases in China and other eastern Asian countries. Recorded in Pharmacopeias of several countries, CM is now drawing increasing attention and under extensive studies in various fields. Phytochemical studies indicate that CM contains many valuable secondary metabolites, such as monoterpene glycosides and phenols. Ample evidence from pharmacological researches suggest that CM has a wide spectrum of activities, such as anti-inflammatory, anti-oxidant, anti-tumor, anti-diabetic, cardiovascular protective, neuroprotective, hepatoprotective effects. Moreover, various analytical methods were established for the quality evaluation and safety control of CM. This review synopsizes updated information concerning the origins, phytochemistry, pharmacology, analytical method and safety of CM, aiming to provide favorable references for modern CM research and application. In conclusion, continuing pharmacological investigations concerning CM should be conducted to unravel its pharmacological mechanisms. Further researches are necessary to obtain comprehensive and applicable analytical approach for quality evaluation and establish harmonized criteria of CM.

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“…Monoterpene glycosides. The structural characteristics included the possession of the "cage-like" pinane skeleton, with different substituent groups, typically glucosyl and phenyl-containing groups [21]. In addition, one feature of the fragmentation in MS/MS was distinctive for the monoterpene glycoside.…”

Section: Qualitative Analysismentioning

confidence: 99%

“…It is notable to highlight that all the 34 phenolic compounds were reported for the first time in tree and herbaceous peony seed oils. The monoterpene glycosides and paeonol derivatives, called "Paeonia glycosides", as a group reported widely as the main bioactive components in Moutan Cortex and other herbal medicines from Paeonia plants [21], have not been reported in other vegetable oils yet.…”

Section: Qualitative Analysismentioning

confidence: 99%

Integrated Profiling of Fatty Acids, Sterols and Phenolic Compounds in Tree and Herbaceous Peony Seed Oils: Marker Screening for New Resources of Vegetable Oil

Wang

Contreras

et al. 2020

Foods

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Tree peonies (Paeonia ostii and Paeonia rockii) are popular ornamental plants. Moreover, these plants have become oil crops in recent years. However, there are limited compositional studies focused on fatty acids. Therefore, this work aims to reveal compositional characteristics, regarding fatty acids, sterols, γ-tocopherol and phenolic compounds, of tree peony seed oils from all major cultivation areas in China, and to compare with herbaceous peony seed oil. For that, an integrative analysis was performed by GC-FID, GC-MS and UHPLC-Q-TOF-MS technologies. The main fatty acid was α-linolenic acid (39.0–48.3%), while β-sitosterol (1802.5–2793.7 mg/kg) and fucosterol (682.2–1225.1 mg/kg) were the dominant phytosterols. Importantly, 34 phenolic compounds, including paeonol and “Paeonia glycosides” (36.62–103.17 μg/g), were characterized in vegetable oils for the first time. Conclusively, this work gives new insights into the phytochemical composition of peony seed oil and reveals the presence of bioactive compounds, including “Paeonia glycosides”.

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UPLC-QTOF-MS based metabolomics coupled with the diagnostic ion exploration strategy for rapidly evaluating sulfur-fumigation caused holistic quality variation in medicinal herbs, Moutan Cortex as an example

Abstract: A novel LC-MS based metabolomics strategy for holistic quality evaluation of sulfur-fumigated herb.

Cited by 17 publications

References 38 publications

Elucidation of Characteristic Sulfur-Fumigated Markers and Chemical Transformation Mechanism for Quality Control of Achyranthes bidentate Blume Using Metabolome and Sulfur Dioxide Residue Analysis

Elucidation of Characteristic Sulfur-Fumigated Markers and Chemical Transformation Mechanism for Quality Control of Achyranthes bidentate Blume Using Metabolome and Sulfur Dioxide Residue Analysis

Origins, Phytochemistry, Pharmacology, Analytical Methods and Safety of Cortex Moutan (Paeonia suffruticosa Andrew): A Systematic Review

Integrated Profiling of Fatty Acids, Sterols and Phenolic Compounds in Tree and Herbaceous Peony Seed Oils: Marker Screening for New Resources of Vegetable Oil

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