UPLC/Q‐TOF–MS‐based metabolomics and molecular docking analysis of Bifidobacterium adolescentis exposure to levofloxacin
Shisui Feng,
Yue Guo,
Qianyi Wang
et al.
Abstract:Antibiotic‐associated diarrhea is a common adverse reaction caused by the widespread use of antibiotics. The decrease in probiotics is one of the reasons why antibiotics cause drug‐induced diarrhea. However, few studies have addressed the intrinsic mechanism of antibiotics inhibiting probiotics. To investigate the underlying mechanism of levofloxacin against Bifidobacterium adolescentis, we used a metabolomics mass spectrometry‐based approach and molecular docking analysis for a levofloxacin‐induced B. adolesc… Show more
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