Upholding or Breaking the Law of Superposition in Pharmacokinetics
Malaz Yousef,
Jaime A. Yáñez,
Raimar Löbenberg
et al.
Abstract:The law of superposition underpins first-order linear pharmacokinetic relationships. Most drugs, therefore, after a single dose can be described by first-order or linear processes, which can be superposed to understand multiple-dose regimen behavior. However, there are a number of situations where drugs could display behaviors after multiple dosing that leads to capacity-limited or saturation non-linear kinetics and the law of superposition is overruled. This review presents a practical guide to understand the… Show more
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