Upfront Surgery for Small Intestinal Non-Hodgkin's Lymphoma

Abstract

Background/Aim: The clinical significance of surgery for secondary small intestinal non-Hodgkin's lymphomas (NHL) remains unknown. This study aimed to investigate the efficacy of resection for both primary and secondary small intestinal NHL. Patients and Methods: Twenty patients with small intestinal lymphoma who underwent surgical resection at our Institute between 2009 and 2017 were retrospectively evaluated. The clinicopathological and surgeryrelated factors were reviewed. We also analyzed their surgical outcomes such as postoperative complications, perforation rate, and overall survival (OS). Results: In total, 13 (65%) and 7 (35%) patients had primary and secondary lymphomas, respectively. A total of 70% of patients were diagnosed with aggressive-type lymphomas. A total of 15 (75%) patients had Lugano system stage IV. Only one (5%) patient experienced postoperative grade II deep vein thrombosis and pulmonary embolism. The 3-year OS rate after surgery was 59.6%. Conclusion: Surgical resection prior to chemotherapy is a feasible and safe therapeutic strategy for small intestinal NHL.

Surgery shows survival benefit in patients with primary intestinal diffuse large B‐cell lymphoma: A population‐based study

“…Hong et al conducted an analysis involving 82 patients to explore the effect of surgery in small intestinal lymphoma, which showed that gross resection contributed to the enhancement of progression‐free survival without obviously increasing the risk of complications 21 . A recent study showed that surgery before chemotherapy is an effective and secure treatment for small intestinal NHL, as it can prevent chemotherapy‐related perforation 20,43 …”

“…Results of GI lymphoma studies are debatable regarding the benefit of surgical excision 3,19 . In recent years, many researchers recommended a combined therapy of chemotherapy and surgery to improve OS 13,20,21 . Due to the potential risk of death and decreased quality of life, the contribution of surgery to PI‐DLBCL needs to be reassessed.…”

Clinical outcome after surgical resection of small bowel cancer

“…21,22 However, there is strong evidence that initial management with surgical resection followed by adjuvant chemotherapy is associated with increased survival. [21][22][23] In our study, this was the standard strategy for management of patients with small bowel lymphoma.…”

Complicaciones quirúrgicas del linfoma con compromiso gastrointestinal

“…Con frecuencia, el diagnóstico se hace después de una intervención quirúrgica, cuando se presenta una complicación, siendo las más frecuentes perforación intestinal, obstrucción y sangrado 1,[10][11][12] .…”