UPEI-400, a conjugate of lipoic acid and scopoletin, mediates neuroprotection in a rat model of ischemia/reperfusion

Connell, Barry J.; Saleh, Monique C.; Rajagopal, D.; Saleh, Tarek M.

doi:10.1016/j.fct.2016.12.026

Cited by 18 publications

(12 citation statements)

References 47 publications

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“…The molecule, used in traditional Chinese medicine, have been investigated for its antioxidant and anti-inflammatory properties [179,180]. Recently, it has been reported that scopoletin is effective in mediating neuroprotection in a rat model of brain ischemia [181]. Moreover, scopoletin was shown to reduce the production of inflammatory cytokines in a human MC line [182].…”

Section: Mcs Modulation: a Promising Strategy In Stroke Treatmentmentioning

confidence: 99%

The Role of Mast Cells in Stroke

Parrella

Porrini

Benarese

et al. 2019

Cells

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Mast cells (MCs) are densely granulated perivascular resident cells of hematopoietic origin. Through the release of preformed mediators stored in their granules and newly synthesized molecules, they are able to initiate, modulate, and prolong the immune response upon activation. Their presence in the central nervous system (CNS) has been documented for more than a century. Over the years, MCs have been associated with various neuroinflammatory conditions of CNS, including stroke. They can exacerbate CNS damage in models of ischemic and hemorrhagic stroke by amplifying the inflammatory responses and promoting brain–blood barrier disruption, brain edema, extravasation, and hemorrhage. Here, we review the role of these peculiar cells in the pathophysiology of stroke, in both immature and adult brain. Further, we discuss the role of MCs as potential targets for the treatment of stroke and the compounds potentially active as MCs modulators.

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Section: Mcs Modulation: a Promising Strategy In Stroke Treatmentmentioning

confidence: 99%

The Role of Mast Cells in Stroke

Parrella

Porrini

Benarese

et al. 2019

Cells

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“…Many investigators claim that quercetin possesses the anti-stroke activity 55,56,57 . Apart from this, coumarin and its derivatives compounds also attenuated the cerebral ischemic/reperfusion injury 58,59,60 . Whereas caffeic acid shown its neuroprotection via LOX and potent antioxidant activity 52,61 .…”

Section: Discussionmentioning

confidence: 94%

Protective Effect of Ethanolic Extract From the Root of Argyreia Speciosa Against Global Cerebral Ischemic Reperfusion Injury in Rats

Jaiswal

Tailang

2018

J. Drug Delivery Ther.

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Cerebral stroke is the principal reason of death without effective treatment in the world and recognized as the common cause of disability. Argyreia speciosa (Linn.f.) (Convolvulaceae, Synonyms: Argyreia nervosa) is widely distributed plant species in India. It is commonly known as Elephant creeper and Vryddhadaru. A. speciosa is a very valuable plant in the Ayurvedic system. In 'Rasayan' drug it has been used for the treatment of various neurological diseases. Its root taste is bitter and having the multiple uses like as a brain tonic, nootropic, anti-anxiety and anticonvulsant activity. The current study, plan to investigate the neuroprotective effect of ethanolic extract of A. speciosa root (ASEE) in a validate rat model of stroke known as global cerebral ischemic reperfusion injury (GCIRI). We divided 36 male Wistar rats to six experimental groups (n= 6). The group-I considered as sham control (no GCIRI), Group-II saline treated GCIRI, Group-III, IV, and V received ASEE (100, 200 and 400 mg/kg, p.o.) for 7 days prior to the induction of GCIRI while Group-VI termed as standard and it received quercetin (20 mg/kg, i.p.) 30 min prior induction of GCIRI. GCIRI produced the significant neurological deficit, sensorimotor dysfunction, decrease neurobehavioral parameters, increased cerebral infarction area and brain edema as compared with sham control rats. Seven days of pretreatment with ASEE markedly attenuates all the changes caused by GCIRI to the normal level. Our results proved that ASEE possess the protective effect on GCIRI induced stroke and aforementioned neuroprotection may be due to its antioxidant and anti-inflammatory property. Keywords: Brain stroke, BCCAO, Antioxidants, Neuroprotection, Argyreia speciosa

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“… ALA-conjugates: PMX500FI 28 , 154 , 155 ; EV06 156 ; Lipoamide-ibuprofen conjugates ( n = 2; 4; 6) 157 , 158 ; Lipoamide-rivastigmine conjugate, Lipocrine 159 ; MiotL, revMitoLipAc 160 ; Scopoletin lipoate. 161 ALA, α-lipoic acid. …”

Section: α-Lipoic Acid and L-carnitinementioning

confidence: 99%

Epigenetic Treatment of Neurodegenerative Ophthalmic Disorders: An Eye Toward the Future

Moos

Faller

Glavas

et al. 2017

BioResearch Open Access

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Eye disease is one of the primary medical conditions that requires attention and therapeutic intervention in ageing populations worldwide. Further, the global burden of diabetes and obesity, along with heart disease, all lead to secondary manifestations of ophthalmic distress. Therefore, there is increased interest in developing innovative new approaches that target various mechanisms and sequelae driving conditions that result in adverse vision. The research challenge is even greater given that the terrain of eye diseases is difficult to landscape into a single therapeutic theme. This report addresses the burden of eye disease due to mitochondrial dysfunction, including antioxidant, autophagic, epigenetic, mitophagic, and other cellular processes that modulate the biomedical end result. In this light, we single out lipoic acid as a potent known natural activator of these pathways, along with alternative and potentially more effective conjugates, which together harness the necessary potency, specificity, and biodistribution parameters required for improved therapeutic outcomes.

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UPEI-400, a conjugate of lipoic acid and scopoletin, mediates neuroprotection in a rat model of ischemia/reperfusion

Cited by 18 publications

References 47 publications

The Role of Mast Cells in Stroke

The Role of Mast Cells in Stroke

Protective Effect of Ethanolic Extract From the Root of Argyreia Speciosa Against Global Cerebral Ischemic Reperfusion Injury in Rats

Epigenetic Treatment of Neurodegenerative Ophthalmic Disorders: An Eye Toward the Future

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