Updating the lipids hypothesis of inflammation and vascular disease in patients with chronic kidney disease: a stearoyl‐<scp>C</scp>o<scp>A</scp> desaturase affair?

Zoccali, Carmine; Mallamaci, Francesca

doi:10.1111/joim.12005

J Intern Med

2012

DOI: 10.1111/joim.12005

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Updating the lipids hypothesis of inflammation and vascular disease in patients with chronic kidney disease: a stearoyl‐CoA desaturase affair?

Carmine Zoccali

Francesca Mallamaci

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Dietary fat modification in patients with chronic kidney disease: n-3 fatty acids and beyond

Huang

Lindholm²,

Stenvinkel³

et al. 2013

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Replacement of dietary saturated fat with unsaturated fat has been recommended for prevention of cardiovascular disease (CVD) in the general population. Less is known of the health risks in individuals with chronic kidney disease (CKD), of a diet with an unhealthy fat profile, in general characterized by insufficient polyunsaturated fatty acids (PUFA) and excess satu-rated fatty acids (SFA). The dietary intake of PUFA, both the n-3 and n-6 subfamilies, is increasingly gaining attention in CKD, owing to its broad cardioprotective effects. Conversely, dietary SFA may promote CVD in this vulnerable population. This review discusses the potential benefits of dietary fat modification in CKD patients, including plausible effects on renal function, albuminuria, lipoproteins, nutritional status, inflammation, thrombosis and clinical outcomes. Increasing evidence supports the concept that n-3 PUFA might have therapeutic potential in reducing proteinuria in CKD and reducing triglycerides and inflammation in dialysis patients. In addition, emerging evidence suggests that linoleic acid, a major n-6 PUFA derived from vegetable oils, may be beneficial for a number of CVD risk factors. Increased consumption of oily fish as part of plant-based diets with low content of SFA is likely to benefit patients who have CKD, or are at risk of developing CKD. Such recommendations are in line with the concept of a healthy "Mediterranean diet" and are in line with current dietary recommendations for CVD prevention in the community.

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Dietary fat modification in patients with chronic kidney disease: n-3 fatty acids and beyond

Huang

Lindholm²,

Stenvinkel³

et al. 2013

View full text Add to dashboard Cite

show abstract

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Updating the lipids hypothesis of inflammation and vascular disease in patients with chronic kidney disease: a stearoyl‐CoA desaturase affair?

Cited by 1 publication

References 21 publications

Dietary fat modification in patients with chronic kidney disease: n-3 fatty acids and beyond

Dietary fat modification in patients with chronic kidney disease: n-3 fatty acids and beyond

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