2019
DOI: 10.1016/j.plipres.2019.101008
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Updates to the n-3 polyunsaturated fatty acid biosynthesis pathway: DHA synthesis rates, tetracosahexaenoic acid and (minimal) retroconversion

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Cited by 67 publications
(55 citation statements)
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References 126 publications
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“…Our data may thus indicate that the chosen dietary levels of EPA + DHA in this study were low. There are also indications that retroconversion of supplemented DHA to EPA occurs in humans, rats, and cell cultures but as reviewed by Metherel and Bazinet (2019) it is more likely that the reason behind this response is a feedback inhibition of EPA elongation to DPA n-3 (e.g., Metherel et al, 2017).…”
Section: Assimilation Of Fatty Acids In Whole Fish and Filetmentioning
confidence: 99%
“…Our data may thus indicate that the chosen dietary levels of EPA + DHA in this study were low. There are also indications that retroconversion of supplemented DHA to EPA occurs in humans, rats, and cell cultures but as reviewed by Metherel and Bazinet (2019) it is more likely that the reason behind this response is a feedback inhibition of EPA elongation to DPA n-3 (e.g., Metherel et al, 2017).…”
Section: Assimilation Of Fatty Acids In Whole Fish and Filetmentioning
confidence: 99%
“…For DHA in mammals the synthesis from EPA involves the ‘Sprecher pathway’ [1,6], with a 24C intermediate and chain shortening by beta-oxidation. However, this biosynthetic route has recently been re-examined [7]. Once 20 or 22C PUFA have been produced they can be subject to oxidation by cyclooxygenase, lipoxygenase or epoxidase enzymes (Figure 2).…”
Section: Introductionmentioning
confidence: 99%
“…However, Δ 4 -desaturase activity could not be detected in mammalian tissues and so the ‘Sprecher pathway’ involving a 24:6 intermediate followed by beta-oxidation was proposed (see [ 83 ]). A recent article has suggested a re-visiting of the situation [ 84 ] but, nevertheless, the Sprecher pathway seems to be key in humans and, with the exception of a few teleost species, in fish also [ 85 ]. Thus, because fish are the main dietary source of n -3 VLCPUFA for humans, it is important that they contain adequate levels of EPA and DHA, and oily fish sources should be from capture fisheries or from aquaculture with an adequate supply of n -3 VLCPUFA in the feed.…”
Section: Production Of Vlcpufas From Dietary Essential Fatty Acidsmentioning
confidence: 99%