Updates on the risk factors of acute kidney injury after transcatheter aortic valve replacement

Cheungpasitporn, Wisit; Kashani, Kianoush

doi:10.15171/jrip.2017.03

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…However, based on the findings of this meta-analysis despite higher statistical power, there was no observed significant association between frailty and the risk of AKI after TAVR. These results suggests that the magnitude of frailty impact on AKI after TAVR is likely small compared to other known risk factors for AKI after TAVR (baseline renal function, transapical approach, blood transfusion and the need for circulatory support) [ 37 – 42 ].…”

Section: Discussionmentioning

confidence: 99%

Association of frailty status with acute kidney injury and mortality after transcatheter aortic valve replacement: A systematic review and meta-analysis

et al. 2017

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ObjectiveFrailty is a common condition in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR). The aim of this systematic review was to assess the impact of frailty status on acute kidney injury (AKI) and mortality after TAVR.MethodsA systematic literature search was conducted using MEDLINE, EMBASE, and Cochrane databases from the inception through November 2016. The protocol for this study is registered with PROSPERO (International Prospective Register of Systematic Reviews; no. CRD42016052350). Studies that reported odds ratios, relative risks or hazard ratios comparing the risk of AKI after TAVR in frail vs. non-frail patients were included. Mortality risk was evaluated among the studies that reported AKI-related outcomes. Pooled risk ratios (RR) and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method.ResultsEight cohort studies with a total of 10,498 patients were identified and included in the meta-analysis. The pooled RR of AKI after TAVR among the frail patients was 1.19 (95% CI 0.97–1.46, I2 = 0), compared with non-frail patients. When the meta-analysis was restricted only to studies with standardized AKI diagnosis according to Valve Academic Research Consortium (VARC)-2 criteria, the pooled RRs of AKI in frail patients was 1.16 (95% CI 0.91–1.47, I2 = 0). Within the selected studies, frailty status was significantly associated with increased mortality (RR 2.01; 95% CI 1.44–2.80, I2 = 58).ConclusionThe findings from our study suggest no significant association between frailty status and AKI after TAVR. However, frailty status is associated with mortality after TAVR and may aid appropriate patient selection for TAVR.

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Section: Discussionmentioning

confidence: 99%

Association of frailty status with acute kidney injury and mortality after transcatheter aortic valve replacement: A systematic review and meta-analysis

et al. 2017

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“…Although prevention and management of overall AKI after TAVR is crucial, if pAKI were known to also be significantly predictive of worse outcomes specifically after TAVR, this knowledge could allow further targeting of high‐risk pAKI patients for a multidisciplinary approach with treatment modification and closer clinical follow‐up to improve outcomes. Risk factors for overall AKI after TAVR have been identified recently, including preexisting chronic kidney disease, transapical approach, need for circulatory support, and periprocedural blood transfusion . However, the incidence and risk factors for pAKI after TAVR are currently not known.…”

Section: Introductionmentioning

confidence: 99%

Persistent acute kidney injury following transcatheter aortic valve replacement

et al. 2017

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“…While diabetics with baseline CKD represent the highest risk patient population for AKI development [128], overall reported risk factors for AKI from the literature include older age, history of diabetes, hypertension, congestive heart failure, peripheral vascular disease, sepsis, use of nephrotoxic drugs, higher severity of disease scores, use of vasopressors/inotropes, high risk surgery, emergency surgery, hemodynamic instability, use of intra-aortic balloon pump, anemia requiring blood transfusion, and longer time in cardiopulmonary bypass pump [129][130][131][132], Table 5.…”

Section: Risk Factorsmentioning

confidence: 99%

Diagnostics, Risk Factors, Treatment and Outcomes of Acute Kidney Injury in a New Paradigm

Thongprayoon

Hansrivijit

Kovvuru

et al. 2020

JCM

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Acute kidney injury (AKI) is a common clinical condition among patients admitted in the hospitals. The condition is associated with both increased short-term and long-term mortality. With the development of a standardized definition for AKI and the acknowledgment of the impact of AKI on patient outcomes, there has been increased recognition of AKI. Two advances from past decades, the usage of computer decision support and the discovery of AKI biomarkers, have the ability to advance the diagnostic method to and further management of AKI. The increasingly widespread use of electronic health records across hospitals has substantially increased the amount of data available to investigators and has shown promise in advancing AKI research. In addition, progress in the finding and validation of different forms of biomarkers of AKI within diversified clinical environments and has provided information and insight on testing, etiology and further prognosis of AKI, leading to future of precision and personalized approach to AKI management. In this this article, we discussed the changing paradigms in AKI: From mechanisms to diagnostics, risk factors, and management of AKI.

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Updates on the risk factors of acute kidney injury after transcatheter aortic valve replacement

Cited by 3 publications

References 10 publications

Association of frailty status with acute kidney injury and mortality after transcatheter aortic valve replacement: A systematic review and meta-analysis

Association of frailty status with acute kidney injury and mortality after transcatheter aortic valve replacement: A systematic review and meta-analysis

Persistent acute kidney injury following transcatheter aortic valve replacement

Diagnostics, Risk Factors, Treatment and Outcomes of Acute Kidney Injury in a New Paradigm

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