Updates on the Management of Non-Melanoma Skin Cancer (NMSC)

Fahradyan, Artur; Howell, Anna C.; Wolfswinkel, Erik M.; Tsuha, Michaela; Sheth, Parthiv; Wong, Alex K.

doi:10.3390/healthcare5040082

Cited by 152 publications

(156 citation statements)

References 215 publications

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“…The number of surgical excisions of the skin tumors with confirmed histopathology has grown. Protocols have been created for the management of skin cancer for proper treatment and to prevent the disease [9]. Moreover, new studies are assessing the QoL of the patients diagnosed with skin cancer [10].…”

Section: Discussionmentioning

confidence: 99%

Quality of Life in Patients with Surgically Removed Skin Tumors

et al. 2020

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Background and Objectives: Skin cancer is one of the most frequently diagnosed malignancies. The main goal of the therapeutic management is total excision with the prevention of recurrence and metastasis. The quality of life of the patients with skin cancer is affected by the morbidity risk, surgery, and cosmetic or functional aspects. The aim of this study was to evaluate the quality of life of patients with skin cancer prior to and post surgical intervention. Material and methods: We performed a prospective study on 247 patients with skin tumors. Quality of life was evaluated through an initial questionnaire that was given to all consenting patients. This was used to determine patients' mobility, selfcare, normal activities, pain, and despair, using a five-point Likert scale. The general autoperceived health state was also recorded using a 100-point scale. The study included the responses of all patients at hospital admission, after one month of surgery, and after one year of surgery. Results: In patients with squamous cell carcinoma (SCC), the general health state indicator statistically significantly decreased one month after surgery and increased at one-year follow-up. In malignant melanoma (MM) patients, mobility, selfcare, normal activities, and discomfort presented a decrease in values one year after surgery, compared to the values registered at hospital admission. In patients with basal cell carcinoma (BCC), all indicators of quality of life presented an impaired value one year after surgery, after a decreasing trend. The general health state indicator statistically significantly increased one month after surgery and after one year. Conclusions: Surgery is one of the main steps in treating skin cancer. It has a great impact on patients' quality of life because of pain andthe effect on mobility and normal activities. Skin cancers influence the quality of life of patients both psychologicallyand physically.

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Section: Discussionmentioning

confidence: 99%

Quality of Life in Patients with Surgically Removed Skin Tumors

et al. 2020

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“…b). Surgical excision, including Mohs micrographic surgery, is recommended as first‐line treatment for most SCC followed by Curettage and electrodessication …”

Section: Discussionmentioning

confidence: 99%

Scalp ulcers – differential diagnoses that should be sought!

2019

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Background Ulceration of the scalp is an uncommon clinical presentation, and it may be caused by myriads of cutaneous etiologies such as infections, inflammatory disorders, and malignancies. We sought to reveal the underlying etiology of scalp ulcers referred to our tertiary wound healing clinic; we would also like to propose a classification for scalp ulcerations.Methods A retrospective study was conducted in an academic tertiary wound healing clinic between January 2015 and June 2018. The study was approved by the Women's College Hospital Institutional Research Ethics Board. We have also conducted a review of the literature to recognize the major causes of scalp ulceration reported in the literature. ResultsWe have identified a total number of 15 patients with scalp ulceration. Twelve patients with atypical scalp ulcers underwent a skin biopsy. A malignancy rate of 73% (11/ 15) was diagnosed histologically. The review of the literature showed 237 articles. After screening the title and the abstracts, we have selected 41 case reports for the full text review.Conclusion Scalp ulcers are uncommon but important. Our sample study indicates the high frequency of malignant etiologies presenting as scalp ulcers. These results emphasize not only the need for clinicians to be on the watch for the possibility of this option but rather highlights the need for early biopsy to prevent further complications. We hope that our paper helps to shed some light on this topic and guide clinicians on how to approach scalp ulceration.

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“…Sağlam cerrahi sınır düşük riskli BCC için 4 mm, düşük risk SCC için 4-6 mm'dir. Fakat daha riskli tümörler için cerrahi sınırın tam olarak değerlendirilmesi önerilir (31). Düşük riskli ve 2 cm den küçük SCC'de 4 mm sağlam sınır, %95 vakada tümörü tamamen çıkarırken, daha büyük tümörler için 6 mm'den daha fazla sağlam sınır gereklidir (32)(33).BCC vakalarında eksizyonu en az 5 mm sağlam cerrahi sınır olacak şekilde yaptık.…”

Section: Gereç Ve Yöntemunclassified

Retrospective Analysis of the Treatment and Follow-up of 251 Patients with Non-melanoma Skin Cancer in the Mediterranean Region

Uslu¹

2019

Acta Oncol Tur.

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ÖZET GİRİŞ ve AMAÇ: Melanom dışı deri kanseri (MDDK) dünya çapında en yaygın kanser tipidir. Bazal hücreli karsinom (BCC; basal cell carcinoma) ve skuamöz hücreli karsinom (SCC; squamous cell carcinoma) MDDK'lerinin % 99'unu oluşturur ve BCC, SCC'dan 3-5 kat sık görülür. Burada, MDDK nedeniyle takip edilen hastaların demografik verileri ve tedavileri, takip sonuçları araştırıldı ve bunlar fark ve benzerlik açısından daha önceki veriler ile karşılaştırıldı. YÖNTEM ve GEREÇLER: Retrospektif olarak, 2014 Ocak-2018 Ocak tarihleri arasında, tek cerrah tarafından MDDK nedeniyle takip ve tedavisi yapılan hastalar incelendi. BULGULAR: Toplam 251 hasta MDDK nedeniyle tedavi ve takip edildi. Hastaların ortalama yaşı 69.9'du. BCC insidansı SCC'nin iki katı bulundu. En fazla tümör lokalizasyonu baş boyun ve baş boyun bölgesinde de en sık lokalizasyon burundu. BCC için 0,5 cm, SCC için 1 cm sağlam cerrahi sınırla eksizyon yapıldı. Rekonstrüksiyon seçeneği olarak çoğunlukla lokal flepler kullanıldı (%61.18). 11 hasta opere edilemedi ve opere edilemeyen tümörlerin 4 tanesi göze invazeydi. Vakaların %4.43'ünde cerrahi sınır pozitif olarak rapor edilirken, 25,82 aylık takipte sadece 4 hastada nüks gözlendi. 17 hastada başka bir bölgede yeni bir MDDK gözlendi. Nüks olan hastaların 3'ü MDDK nedeniyle öldü. TARTIŞMA ve SONUÇ: MDDK tanısı fizik muayene ile çok rahat konulabilmektedir. Biyopsi her vakada gerekli değildir. Burada, SCC oranı önceki çalışmalardan farklı olarak beklenenden daha fazla bulundu. Tedavide rekonstrüksiyon seçeneği olarak daha çok lokal flepler tercih edildi. Cerrahi sınır pozitif hasta sayısı (%4.27) ve nüks oranı (%1.31) oldukça az bulundu. Bu da, tedavide flep seçeneğinin tercih edilmesine bağlı tabandan yeterli derinlikte eksizyon yapılmasına ve takip süresinin 5 yıldan kısa olmasına bağlanabilir. Anahtar Kelimeler: Bazal hücreli karsinom, skuamöz hücreli karsinom, melanom dışı deri kanseri, deri kanseri. ABSTRACT INTRODUCTION:Non-melanoma skin cancer (NMSC) is the most common type of cancer worldwide. Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) constitute 99% of NMSCs, with BCC being 3-5 times more common than SCC. This study analyzed the demographic data, treatment and follow-up of patients with NMSC and compared the results with those of previous studies. METHODS: Patients who had been followed-up and treated for NMSC by a single surgeon between January 2014 and January 2018 were evaluated retrospectively. RESULTS: The average age of the 251 patients treated and followed for NMSC was 69.9 years. The incidence of BCC was found to be two times of the SCC. The most frequent tumor localization was the head and neck. Among the head and neck tumors, the incidence of nasal tumors was the highest. Intact surgical margin excisions of 0.5 cm for BCC and 1 cm for SCC were performed. Local flaps were the most common reconstruction option (61.18%). Eleven patients could not be operated on and four of the unoperable tumors were invased to the eye. Positive surgical margins were determined in 4.43% of ...

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Updates on the Management of Non-Melanoma Skin Cancer (NMSC)

Cited by 152 publications

References 215 publications

Quality of Life in Patients with Surgically Removed Skin Tumors

Quality of Life in Patients with Surgically Removed Skin Tumors

Scalp ulcers – differential diagnoses that should be sought!

Retrospective Analysis of the Treatment and Follow-up of 251 Patients with Non-melanoma Skin Cancer in the Mediterranean Region

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