2021
DOI: 10.1016/j.scitotenv.2021.149280
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Updates on the global dissemination of colistin-resistant Escherichia coli: An emerging threat to public health

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Cited by 36 publications
(24 citation statements)
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“…It is apparent that the use of colistin created selective pressure favoring bacteria carrying mcr-1 . The gene was most commonly found on IncI2 plasmids [ 22 ].…”
Section: Discussionmentioning
confidence: 99%
“…It is apparent that the use of colistin created selective pressure favoring bacteria carrying mcr-1 . The gene was most commonly found on IncI2 plasmids [ 22 ].…”
Section: Discussionmentioning
confidence: 99%
“…Although initially detected as being harboured on an IncI plasmid, it has been shown that carriage of the mcr-1 gene in nature can occur on various plasmid types, including IncF, IncHI2, IncP, IncX4 and IncY [109]. Furthermore, the reservoirs of mcr-1-bearing plasmids are similarly wide-ranging, with these mobile genetic elements identified in food (meat/ vegetables), aquatic environments, hospital sewage, infected/colonized humans, wild birds/animals and especially predominantly in farm animals [112][113][114]. It is hypothesized that livestock, particularly cattle and pigs, are a major source and driver of global mcr-1 spread, and the extensive use of colistin in veterinary medicine as a growth promoter has only served to accelerate and exacerbate this problem [115].…”
Section: Polymyxin Resistance Via Acquired Genesmentioning
confidence: 99%
“…Resistant E. coli have been widely reported worldwide from humans, livestock, companion animals, and environmental sources as wildlife [ 3 , 8 , 23 ]. Wild animals are not normally treated with antibiotics but the direct and indirect contact with humans, livestock, domestic animals, or anthropic areas can promote the sharing of commensal or pathogenic bacteria as well as their relative resistance genes [ 24 ], highlighting that different ecological niches may have an impact on the dissemination of antimicrobial resistance determinants.…”
Section: Introductionmentioning
confidence: 99%