Updates on Recent Clinical Assessment of Commercial Chronic Wound Care Products

Abstract

Impaired wound healing after trauma, disorders, and surgeries impact millions of people globally every year. Dysregulation in orchestrated healing mechanisms and underlying medical complications make chronic wound management extremely challenging. Besides standard‐of‐care treatments including broad spectrum antibiotics and wound‐debridement, novel adjuvant therapies are clinically tested and commercialized. These include topical agents, skin substitutes, growth factor delivery, and stem cell therapies. With a goal to overcome factors playing pivotal role in delayed wound healing, researchers are exploring novel approaches to elicit desirable healing outcomes in chronic wounds. Although recent innovations in wound care products, therapies, and devices are extensively reviewed in past, a comprehensive review summarizing their clinical outcomes is surprisingly lacking. Herein, this work reviews the commercially available wound care products and their performance in clinical trials to provide a statistically comprehensive understanding of their safety and efficacy. The performance and suitability of various commercial wound care platforms, including xenogeneic and allogenic products, wound care devices, and novel biomaterials, are discussed for chronic wounds. The current clinical evaluation will provide a comprehensive understanding of the benefits and drawbacks of the most‐recent approaches and will enable researchers and healthcare providers to develop next‐generation technologies for chronic wound management.

Carbon Dots’ Potential in Wound Healing: Inducing M2 Macrophage Polarization and Demonstrating Antibacterial Properties for Accelerated Recovery

“…The RT-PCR observation (Figure C) was consistent with the amounts of the aforementioned pro- and anti-inflammatory cytokines assessed by ELISA (Figure D). The results revealed that the suppression of pro-inflammatory cytokines and activation of anti-inflammatory cytokines could be mediated through the polarization into M 2 macrophages, which would attribute to the healing mechanism of chronic wounds. , …”

Ceramic Dressings—A New Non-Pharmacological Therapeutic Option in the Management of Chronic Wounds?

“…Moreover, the ceramic dressing showed bacterial retention properties and even demonstrated superior diagnostic properties compared to conventional wound swabs. The majority of chronic wounds do not progress beyond the inflammatory stage, which is characterized by poor perfusion, persistent inflammation, and bacterial burden [20][21][22]. These interactions lead to hard-to-heal wounds characterized by stagnated wound sizes.…”

Application of pulsed electric field technology to skin engineering

“…As a biomaterial, collagen can interact with cells and the ECM of the recipient to promote cellular proliferation ( Parenteau-Bareil et al, 2010 ). Mammalian collagen scaffolds include Bio-ConneKt and HeliColl, among others ( Table 1 ) ( Sharma et al, 2023 ). Unfortunately, mammalian collagen has been associated with immunogenicity following implantation, with ethical controversy complicating its use ( Parenteau-Bareil et al, 2010 ).…”