Updates on Mechanisms of Cytochrome P450 Catalysis of Complex Steroid Oxidations
F. Peter Guengerich,
Yasuhiro Tateishi,
Kevin D. McCarty
et al.
Abstract:Cytochrome P450 (P450) enzymes dominate steroid metabolism. In general, the simple C-hydroxylation reactions are mechanistically straightforward and are generally agreed to involve a perferryl oxygen species (formally FeO3+). Several of the steroid transformations are more complex and involve C-C bond scission. We initiated mechanistic studies with several of these (i.e., 11A1, 17A1, 19A1, and 51A1) and have now established that the dominant modes of catalysis for P450s 19A1 and 51A1 involve a ferric peroxide … Show more
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