Updates on corneal collagen cross-linking: Indications, techniques and clinical outcomes

Mohammadpour, Mehrdad; Masoumi, Ahmad; Mirghorbani, Masoud; Shahraki, Kianoosh; Hashemi, Hassan

doi:10.1016/j.joco.2017.07.003

Cited by 39 publications

(27 citation statements)

References 150 publications

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“…Several studies have reported a thinning of the pachymetry measurements obtained from topography in the early period after CXL treatment, but in the late postoperative period, these values have approached the pre-treatment levels (6,18,19). Therefore, pachymetric analyses may cause errors in progression analysis after CXL.…”

Section: Discussionmentioning

confidence: 99%

Progression Analysis With ABCD Grading System Following Corneal Collagen Cross-Linking in Keratoconus

Sağlık¹

2019

Beyoglu Eye J

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To evaluate the ABCD grading system used in follow-up of keratoconus progression after the corneal collagen cross-linking (CXL) treatment in different Kmax groups. Methods: This study included 57 eyes of 43 patients applied with CXL treatment for progressive keratoconus. All the patients were applied with the standard CXL protocol (Dresden). According to the changes in the Kmax value at the end of 12 months postoperatively (0-1D, 1-2D, >2D), the groups were separated as steepening and flattening. Scheimpflug progression parameters, such as ABCD keratoconus grading systems, were evaluated in six different groups. The Paired Samples t-test was used in the evaluation of parameters with normal distribution and the Wilcoxon test for parameters not showing normal distribution. A value of p<0.05 was accepted as statistically significant. Results: Mean age of patients was 18.37±3.86 years (11-28 years). According to the ABCD grading system, 0.19 significant regression was determined in grade A (p=0.014) and 0.24 in grade D (p<0.0001). 0.10 progression was seen in grade B (p=0.089), and 0.11 in grade C (p=0.011). In the mean Kmax value 0.25±0.42, D flattening was seen (p=0.137). Conclusion: The anterior corneal surface grade in ABCD system is correlated with Kmax in different groups. However, the posterior corneal surface parameter is not correlated with Kmax in 1-2 D steepening and >2D flattening groups. Although there is an increase in posterior elevation after CXL, despite excessive Kmax flattening, it would be inaccurate to consider this increase as an indicator of topographic progress.

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Section: Discussionmentioning

confidence: 99%

Progression Analysis With ABCD Grading System Following Corneal Collagen Cross-Linking in Keratoconus

Sağlık¹

2019

Beyoglu Eye J

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“…However, CXL does not improve visual defects. To address this limitation, combining CXL with photorefractive keratectomy (PRK) can not only restore corneal stability but can also improve vision; however, the long-term safety and stability of this combined technique has yet to be established ( Mohammadpour et al, 2017 ). In addition, cyclosporine A can be used to treat epithelial dysfunction in dry eye, but it can be expensive, and side-effects include eye burns ( de Paiva et al, 2019 ).…”

Section: Targeting Cilia For Corneal Disease Treatmentmentioning

confidence: 99%

Primary cilia in corneal development and disease

Song¹,

Zhou

2020

Zoological Research

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As a transparent avascular tissue located at the front of the eyeball, the cornea is an important barrier to external damage. Both epithelial and endothelial cells of the cornea harbor primary cilia, which sense changes in the external environment and regulate intracellular signaling pathways. Accumulating evidence suggests that the primary cilium regulates corneal development in several ways, including participation in corneal epithelial stratification and maintenance of corneal endothelial cell morphology. In addition, the primary cilium has been implicated in the pathogenesis of several corneal diseases. In this review, we discuss recent findings that demonstrate the critical role of the primary cilium in corneal development. We also discuss the link between ciliary dysfunction and corneal diseases, which suggests that the primary cilium could be targeted to treat these diseases.

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“…Najczęściej występującym powikłaniem jest zaburzenie przejrzystości rogówki, które występuje w 8,6% przypadków, lecz dotyczy głównie stożków bardziej zaawansowanych. Rzadziej obserwuje się przejściowy obrzęk rogówki lub zakażenia związane z ubytkiem nabłonka i stosowaniem opatrunkowych szkieł kontaktowych [25].…”

Section: Leczenieunclassified

Aktualności w diagnostyce i leczeniu stożka rogówki

Roszkowska¹

2018

PiS

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Stożek rogówki jest chorobą degeneracyjną, polegającą na postępującym ścieńczeniu i uwypukleniu rogówki. Choroba ta, w postaciach zaawansowanych, prowadzi do znacznych zaburzeń ostrości wzroku-jedynym rozwiązaniem staje się wówczas przeszczep rogówki. Nowoczesna diagnostyka stożka bazuje na analizie powierzchni rogówki przy użyciu topo-tomografi i komputerowej, która pozwala na ocenę wczesnych zmian chorobowych z możliwością wdrożenia odpowiedniego leczenia w stadiach początkowych. Taką procedurą jest wprowadzone w ostatnich latach sieciowanie włókien kolagenowych. Zabieg ten, dzięki reakcji fotochemicznej wywołanej oddziaływaniem UVA i rybofl awiny, prowadzi do tworzenia nowych wiązań pomiędzy łańcuchami kolagenu, z następującym usztywnieniem miąższu rogówki i zahamowaniem rozwoju stożka. Wczesna diagnoza, możliwa dzięki obrazowaniu rogówki przy użyciu nowoczesnych systemów topo-tomografi cznych w połączeniu z efektywnym zabiegiem powstrzymującym rozwój stożka, stanowią istotne osiągniecie ostatnich lat.

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Updates on corneal collagen cross-linking: Indications, techniques and clinical outcomes

Cited by 39 publications

References 150 publications

Progression Analysis With ABCD Grading System Following Corneal Collagen Cross-Linking in Keratoconus

Progression Analysis With ABCD Grading System Following Corneal Collagen Cross-Linking in Keratoconus

Primary cilia in corneal development and disease

Aktualności w diagnostyce i leczeniu stożka rogówki

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