Updates in the Management of Peripheral Arterial Disease: Focus on Reduction of Atherothrombotic Risk

Brunton,

doi:10.12788/jfp.0290

Cited by 2 publications

(3 citation statements)

References 40 publications

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“… Risk Factors for Lower Extremity Peripheral Arterial Disease [ 1 , 2 , 3 , 4 , 6 , 7 , 8 , 12 , 14 , 15 ] CVD: Cardiovascular disease. …”

Section: Figurementioning

confidence: 99%

“…Lower extremity artery disease (LEAD), also called lower extremity peripheral artery disease (PAD) or lower extremity PAD, belongs to the large PAD family and is a chronic obstruction characterized by decreased blood flow to the arteries of the extremities of the lower limbs, which causes ischemia, with possible thromboembolic complications [ 1 , 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…LEAD risk factors are classified into two categories: modifiable risk factors (hypercholesterolemia, smoking, DM (diabetes mellitus), systolic hypertension, sedentary lifestyle), and non-modifiable risk factors (age > 50 years, sex, family history of LEAD, chronic kidney disease) ( Figure 1 ) [ 1 , 2 , 3 , 4 , 6 , 7 , 8 , 12 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

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The Genetic Architecture of the Etiology of Lower Extremity Peripheral Artery Disease: Current Knowledge and Future Challenges in the Era of Genomic Medicine

Butnariu

Gorduza

Florea

et al. 2022

IJMS

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Lower extremity artery disease (LEAD), caused by atherosclerotic obstruction of the arteries of the lower limb extremities, has exhibited an increase in mortality and morbidity worldwide. The phenotypic variability of LEAD is correlated with its complex, multifactorial etiology. In addition to traditional risk factors, it has been shown that the interaction between genetic factors (epistasis) or between genes and the environment potentially have an independent role in the development and progression of LEAD. In recent years, progress has been made in identifying genetic variants associated with LEAD, by Genome-Wide Association Studies (GWAS), Whole Exome Sequencing (WES) studies, and epigenetic profiling. The aim of this review is to present the current knowledge about the genetic factors involved in the etiopathogenic mechanisms of LEAD, as well as possible directions for future research. We analyzed data from the literature, starting with candidate gene-based association studies, and then continuing with extensive association studies, such as GWAS and WES. The results of these studies showed that the genetic architecture of LEAD is extremely heterogeneous. In the future, the identification of new genetic factors will allow for the development of targeted molecular therapies, and the use of polygenic risk scores (PRS) to identify individuals at an increased risk of LEAD will allow for early prophylactic measures and personalized therapy to improve their prognosis.

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“… Risk Factors for Lower Extremity Peripheral Arterial Disease [ 1 , 2 , 3 , 4 , 6 , 7 , 8 , 12 , 14 , 15 ] CVD: Cardiovascular disease. …”

Section: Figurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Genetic Architecture of the Etiology of Lower Extremity Peripheral Artery Disease: Current Knowledge and Future Challenges in the Era of Genomic Medicine

Butnariu

Gorduza

Florea

et al. 2022

IJMS

View full text Add to dashboard Cite

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Diagnosis and treatment of peripheral vascular disease. Literature review

Rodríguez¹,

Domínguez²,

Sandoval³

et al. 2022

Angiologia

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La enfermedad arterial periférica tiene lugar debido a la obstrucción a nivel arterial. Esta obstrucción está dada principalmente por la ateroesclerosis resultante a su vez de la acumulación de lípidos y de material fibroso entre la túnica íntima y muscular propia de la pared de los vasos sanguíneos. La consecuente disminución del flujo sanguíneo puede presentarse de manera asintomática o manifestarse con síntomas de insuficiencia arterial como: claudicación intermitente, dolor en reposo en el grupo muscular afectado o pérdida tisular (úlceras). Esta última es uno de los signos más evidentes de isquemia de la extremidad. Los factores de riesgo son similares a los factores de riesgo cardiovascular (hipertensión arterial, tabaquismo, hiperlipidemias, diabetes o síndrome metabólico). Para llevar a cabo su diagnóstico se requiere una adecuada historia clínica, un examen físico exhaustivo (disminución de pulsos periféricos), el índice tobillobrazo (ITB) y, además, la utilización de herramientas diagnósticas como son: dúplex, la tomografía computarizada y la resonancia magnética. El manejo dependerá del estadio de la enfermedad y va dirigido al alivio de los síntomas y a la disminución del riesgo de progresión de enfermedad cardiovascular.

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Updates in the Management of Peripheral Arterial Disease: Focus on Reduction of Atherothrombotic Risk

Cited by 2 publications

References 40 publications

The Genetic Architecture of the Etiology of Lower Extremity Peripheral Artery Disease: Current Knowledge and Future Challenges in the Era of Genomic Medicine

The Genetic Architecture of the Etiology of Lower Extremity Peripheral Artery Disease: Current Knowledge and Future Challenges in the Era of Genomic Medicine

Diagnosis and treatment of peripheral vascular disease. Literature review

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