Updated review on green tea polyphenol epigallocatechin-3-gallate as a cancer epigenetic regulator

Li, Feng; Qasim, Syeda; Li, Dapeng; Dou, Q. Ping

doi:10.1016/j.semcancer.2020.11.018

Cited by 40 publications

(33 citation statements)

References 271 publications

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“…Epigallocatechin-3-gallate (EGCG) is a green tea polyphenol that has attracted much attention in recent years for cancer and other diseases (F. Li, Qasim, Li, & Dou, 2021). EGCG administration can be used to inhibit cancer progression via affecting cancer stem cells (P. .…”

Section: Boosting Cytotoxicitymentioning

confidence: 99%

Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects

Abadi

Mirzaei

Mahabady

et al. 2021

Phytotherapy Research

120

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Section: Boosting Cytotoxicitymentioning

confidence: 99%

Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects

Abadi

Mirzaei

Mahabady

et al. 2021

Phytotherapy Research

120

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“…Some examples of these well-characterized compounds include (epi)gallocatechin gallate (13), coumaroyl-O-galloyl-glucose ( 21), (3,4,5-trihydroxy-6-(4-(1-hydroxypropan-2yl)-2-methoxyphenoxy)tetrahydro-2H-pyran-2-yl)methyl-3,4,5-trihydroxybenzoate (25), myricitrin (31) and quercitrin (41), which are the major compounds in the studied extract of S. pucherrimum. (Epi)gallocatechin gallate (13) and its analogues have been reported as proteasome inhibitors [75], preventers of degenerative brain diseases [76], antibacterial [77], antiviral, antifungal [78], part of cancer treatments [79,80] and modulators of cyclooxygenase-2, oxidative stress and inflammation of different cellular processes [80]. Coumaroyl-O-galloyl-glucose (21) has been reported in extracts with wound healing properties [81] and antioxidant, anti-inflammatory, antimutagenic, antimicrobial [82] and antidiarrheal activities [83].…”

Section: Discussionmentioning

confidence: 99%

Feature-Based Molecular Network-Guided Dereplication of Natural Bioactive Products from Leaves of Stryphnodendron pulcherrimum (Willd.) Hochr

et al. 2021

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Stryphnodendron pulcherrimum is a species known to have a high content of tannins. Accordingly, its preparations are used in southern Pará, Brazil, for their anti-inflammatory and antimicrobial activities, but so far, its chemical profile composition remains essentially unknown. We herein describe the compounds present in a hydro-acetonic extract from S. pulcherrimum leaves as revealed by dereplication via ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry. The data were combined with spectral organization, spectral matching through the Global Natural Products Social platform, in silico annotation and taxonomical ponderation. Several types of phenolic compounds were identified such as gallic acids, flavan-3-ols and flavone-like compounds. From these, 5 have been recently reported by our group, whereas 44 are reported here for the first time in this tree species, and 41 (out of 49) for this genus. The results highlight the possible role of Stryphnodendron pulcherrimum as a renewable source for natural bioactive products with potential pharmaceutical applications.

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“…Interestingly, it has been suggested that resveratrol may regulate the expression of tumor suppressor genes by interaction with miRNAs, including mir-21, an important player in renal tumor development [ 119 ]. Another polyphenol, EGCG, has been reported to promote the expression of different tumor suppressor genes by interacting with miR-210, which is downregulated in several types of tumors, including RCC [ 120 ]. EGCG has been reported to inhibit cell proliferation and induce apoptosis in 786-O cells, by inducing the overexpression of TFPI-2 (tissue factor pathway inhibitor-2) [ 121 ].…”

Section: Implication Of Polyphenols In Renal Pathophysiologymentioning

confidence: 99%

Polyphenols and Their Metabolites in Renal Diseases: An Overview

Guerreiro

Ferreira-Pêgo

Carregosa

et al. 2022

Foods

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Kidney diseases constitute a worldwide public health problem, contributing to morbidity and mortality. The present study aimed to provide an overview of the published data regarding the potential beneficial effects of polyphenols on major kidney diseases, namely acute kidney injury, chronic kidney disease, diabetic nephropathy, renal cancer, and drug-induced nephrotoxicity. This study consists of a bibliographical review including in vitro and in vivo studies dealing with the effects of individual compounds. An analysis of the polyphenol metabolome in human urine was also conducted to estimate those compounds that are most likely to be responsible for the kidney protective effects of polyphenols. The biological effects of polyphenols can be highly attributed to the modulation of specific signaling cascades including those involved in oxidative stress responses, anti-inflammation processes, and apoptosis. There is increasing evidence that polyphenols afford great potential in renal disease protection. However, this evidence (especially when in vitro studies are involved) should be considered with caution before its clinical translation, particularly due to the unfavorable pharmacokinetics and extensive metabolization that polyphenols undergo in the human body. Future research should consider polyphenols and their metabolites that indeed reach kidney tissues.

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Updated review on green tea polyphenol epigallocatechin-3-gallate as a cancer epigenetic regulator

Cited by 40 publications

References 271 publications

Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects

Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects

Feature-Based Molecular Network-Guided Dereplication of Natural Bioactive Products from Leaves of Stryphnodendron pulcherrimum (Willd.) Hochr

Polyphenols and Their Metabolites in Renal Diseases: An Overview

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