Updated reference ranges for aminotransferase levels of Korean children and young adolescents based on the risk factors for metabolic syndrome

Seo, Young-Jun; Shim, Young‐Soo; Lee, Hae Sang; Hwang, Jin Soon

doi:10.1038/s41598-022-20104-y

Cited by 2 publications

(2 citation statements)

References 37 publications

(46 reference statements)

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“…The liver enzymes (AST, ALT and γ–GTP) level at 11–12 years of age was higher in high BMI trajectory group than low BMI trajectory group. The AST/ALT ratio was low in the high BMI group, in line with a previous report [ 26 ].…”

Section: Discussionsupporting

confidence: 92%

Synergistic effect of serum uric acid and body mass index trajectories during middle to late childhood on elevation of liver enzymes in early adolescence: Findings from the Ewha Birth and Growth Study

et al. 2023

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Background/objectives We aimed to determine whether serum uric acid (SUA) and body mass index (BMI) trajectories in childhood have longitudinal association with liver enzymes in adolescence. Methods We conducted a study using data from the Ewha Birth and Growth Cohort. Individual trajectories of SUA (n = 203) and BMI (n = 206) from 5, 7, and 9 years were defined by group-based trajectory modeling. Also, liver function enzymes were collected at 11 to 12 year of age (Aspartate Aminotransferase [AST], Alanine transaminase [ALT], and Gamma-glutamyl transferase [γ–GTP]) (n = 206). Using a generalized linear model, the effects of SUA trajectory and BMI trajectory on liver function enzymes were assessed. We also assessed the interaction effect of SUA and BMI trajectories on liver enzymes. Results For trajectory patterns, both SUA and BMI were classified into two distinct groups (High or Low). Both trajectory of SUA and BMI in childhood were positively associated with levels of liver enzymes at 11–12 years of age. The results showed that the combined effect of SUA and BMI trajectories on liver enzymes had a higher means in high-risk group (high SUA–high BMI trajectories group) than in low-risk group (low SUA-low BMI trajectories group) for ALT and γ–GTP, respectively. It remained significant association when adjusted for covariates. In addition, the interaction of BMI and SUA trajectories showed a significant synergistic effect. Conclusion Elevated childhood SUA and BMI trajectories are associated with increased liver enzymes in beginning of adolescent. This finding suggesting that early interventions in SUA and BMI may need for optimization of liver enzymes as potential marker for development of related disease in later life.

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Section: Discussionsupporting

confidence: 92%

Synergistic effect of serum uric acid and body mass index trajectories during middle to late childhood on elevation of liver enzymes in early adolescence: Findings from the Ewha Birth and Growth Study

et al. 2023

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“…Additional anthropometric indices related to obesity are also being studied, such as the waist-hip ratio and the waist-height ratio (WHtR). WHtR has been suggested as the most reliable anthropometric method of measuring body fat mass [ 10 - 12 ] and is evaluated as an indicator of cardiometabolic risks [ 13 , 14 ]. In this study, we investigate standard deviation score (SDS) of WHtR and BMI as indicators of cardiometabolic risk and body fat composition in Korean children and adolescents.…”

Section: Introductionmentioning

confidence: 99%

Waist-height ratio and body mass index as indicators of obesity and cardiometabolic risk in Korean children and adolescents

Kim,

An,

Shim

et al. 2024

Ann Pediatr Endocrinol Metab

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Purpose: We assessed the clinical relevance of waist-height ratio (WHtR) as an indicator of cardiometabolic risk and body fat mass measured by dual-energy x-ray absorptiometry (DXA) among Korean children and adolescents.Methods: Data from 1,661 children and adolescents aged 10–18 years who participated in the Korea National Health and Nutrition Examination Survey were analyzed. Unadjusted Pearson correlation, age- and sex-adjusted Pearson correlation, and multiple linear regression analyses were performed to investigate the relationships between WHtR standard deviation score (SDS) and cardiometabolic risk factors, as well as DXA-assessed parameters.Results: WHtR SDS was correlated with cardiometabolic risk factors, including systolic blood pressure, glucose, total cholesterol, high-density lipoprotein cholesterol, triglyceride, and low-density lipoprotein cholesterol, as well as DXA-assessed parameters such as lean mass SDS, fat mass SDS, and fat mass percentage SDS in both whole body and trunk using an adjusted Pearson correlation analyses among all participants (p<0.001). WHtR SDS was strongly correlated with whole-body fat mass and trunk fat mass (r=0.792, p<0.001 and r=0.801, p<0.001, respectively) whereas WHtR SDS had a low correlation coefficient with whole-body lean mass and trunk lean mass SDS (r=0.512, p<0.001 and r=0.487, p<0.001, respectively). In multiple linear regression analyses, WHtR SDS was significantly associated with whole-body and trunk fat mass after adjustment for confounders.Conclusion: Cardiometabolic risk factors and body fat mass assessed by DXA in Korean children and adolescents were highly correlated with WHtR. Additionally, WHtR has an advantage in distinguishing fat-free mass. WHtR can be a useful and convenient clinical indicator of cardiometabolic risk factors.

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Updated reference ranges for aminotransferase levels of Korean children and young adolescents based on the risk factors for metabolic syndrome

Cited by 2 publications

References 37 publications

Synergistic effect of serum uric acid and body mass index trajectories during middle to late childhood on elevation of liver enzymes in early adolescence: Findings from the Ewha Birth and Growth Study

Synergistic effect of serum uric acid and body mass index trajectories during middle to late childhood on elevation of liver enzymes in early adolescence: Findings from the Ewha Birth and Growth Study

Waist-height ratio and body mass index as indicators of obesity and cardiometabolic risk in Korean children and adolescents

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