Updated PRIMA consensus document to assist the practicing physician

Reviakina, Vera; Revyakina, V A; Астафьева, Н. Г.; Григорьевна, Астафьева Наталья; Геппе, Н.А.; Анатольевна, Геппе Наталья; Калюжин, О. В.; Витальевич, Калюжин Олег

doi:10.26442/26586630.2021.2.200992

Cited by 2 publications

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“…Currently, there are various approaches to the treatment of ARVI-some countries recommend only symptomatic treatment, with the exception of influenza and RSV infection, while others in addition recommend a wide range of drugs with antiviral action, including those that can affect the immune system-so-called immunotropic drugs [56][57][58][59][60]. Immunotropic drugs focus primarily on supporting and providing antiviral immunity.…”

Section: Approaches To the Treatment Of Arvimentioning

confidence: 99%

The Common Cold and Influenza in Children: To Treat or Not to Treat?

et al. 2023

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The common cold, which is mostly caused by respiratory viruses and clinically represented by the symptoms of acute respiratory viral infections (ARVI) with mainly upper respiratory tract involvement, is an important problem in pediatric practice. Due to the high prevalence, socio-economic burden, and lack of effective prevention measures (except for influenza and, partially, RSV infection), ARVI require strong medical attention. The purpose of this descriptive literature review was to analyze the current practical approaches to the treatment of ARVI to facilitate the choice of therapy in routine practice. This descriptive overview includes information on the causative agents of ARVI. Special attention is paid to the role of interferon gamma as a cytokine with antiviral and immunomodulatory effects on the pathogenesis of ARVI. Modern approaches to the treatment of ARVI, including antiviral, pathogenesis-directed and symptomatic therapy are presented. The emphasis is on the use of antibody-based drugs in the immunoprophylaxis and immunotherapy of ARVI. The data presented in this review allow us to conclude that a modern, balanced and evidence-based approach to the choice of ARVI treatment in children should be used in clinical practice. The published results of clinical trials and systematic reviews with meta-analyses of ARVI in children allow us to conclude that it is possible and expedient to use broad-spectrum antiviral drugs in complex therapy. This approach can provide an adequate response of the child’s immune system to the virus without limiting the clinical possibilities of using only symptomatic therapy.

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Section: Approaches To the Treatment Of Arvimentioning

confidence: 99%

The Common Cold and Influenza in Children: To Treat or Not to Treat?

et al. 2023

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“…Новикова, «подозрение на наличие у пациента вторичной иммунной недостаточности должно основываться на результатах комплексного обследования -сбора подробного анамнеза жизни, истории развития заболевания, оценке клинических проявлений патологического процесса, результатах клинико-лабораторного и иммунологического обследования» [17]. Для констатации и верификации иммунологических нарушений требуется их лабораторная диагностика [18] При назначении иммуномодулирующей терапии целесообразно придерживаться следующих принципов [20]:…”

Section: задачи иммунотропной терапииunclassified

“…По мнению других авторов, абсолютными показаниями для назначения иммунотропных препаратов считаются [20]:…”

Section: задачи иммунотропной терапииunclassified

“…-лечение детей, которые болеют ОРВИ 9 и более раз в год, длительно и с осложнениями; -лечение детей, страдающих атопическим дерматитом, с сопутствующей персистирующей инфекцией» [20].…”

Section: задачи иммунотропной терапииunclassified

“…Амбулаторно иммунотропные препараты показаны следующим группам часто болеющему детскому населению [20]:…”

Section: задачи иммунотропной терапииunclassified

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Immunotherapy at the modern stage: types and tactics of application

Korzhenevsky

Korzhenevskaya

2022

Vestn. Ross. univ. družby nar., Ser. Med.

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The sum of the effects of all negative factors on the human body is manifested, including in the form of an imbalance in the work of the immune system, which leads to a violation of the recognition and elimination of foreign substances of the most diverse origin. This is manifested in an increase in the frequency of development of inflammatory processes, the risk of their chronicity and the development of complications, the identification of opportunistic or conditionally pathogenic flora as a pathogen, including those with atypical biological properties and antibiotic resistance. The use of etiotropic chemotherapy alone in the treatment does not allow achieving sufficient control over many infectious diseases. The purpose of this review was to investigate additional, alternative approaches to influencing anti-infective immunity. An analysis of the strategy based on the use of modulation of the immune response in the treatment of patients was carried out and its advantages over traditional antimicrobial treatment were determined. The concept of «immunotherapy» is discussed, which implies a variety of effects on the immune system in order to stop the pathological process. The review highlights the main types of immunotherapy - local, general, combined and monoimmunotherapy, as well as active and passive, specific and nonspecific. The review provides convincing data on the need for immunomodulators to meet a number of requirements, analyzes various ways of classifying them and their areas of application. The necessity of using immunotropic drugs on the basis of a comprehensive examination is emphasized, taking into account the correspondence between the nature of clinical manifestations and the severity of changes in immunological parameters. The analyzed data allow us to conclude that immunomodulatory therapy can be used to restore the function of the immune system to the physiological norm after a severe inflammatory process at the stage of immunorehabilitation.

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Updated PRIMA consensus document to assist the practicing physician

Abstract: The PRIMA Consensus document developed by leading Russian experts reviews the principles of outpatient immunotherapy in children with frequent acute respiratory viral infections.

Cited by 2 publications

References 1 publication

The Common Cold and Influenza in Children: To Treat or Not to Treat?

The Common Cold and Influenza in Children: To Treat or Not to Treat?

Immunotherapy at the modern stage: types and tactics of application

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