Updated Nomogram Predicting Lymph Node Invasion in Patients with Prostate Cancer Undergoing Extended Pelvic Lymph Node Dissection: The Essential Importance of Percentage of Positive Cores

CEACAM5 is correlated with Angio/Lymphangiogenesis of Prostatic Lesions

“…This might suggest that CEACAM5 positive expression and transformation of expression patterns should promote tumor progression. Briganti A's study showed the clinical stage, primary biopsy Gleason grade, and percentage of positive cores were independent predictors of lymph node invasion in patients with PCa [23]. In our study, the CEACAM5 in PCa was significantly associated with the score of the Gleason grading, the pathological stage, and the MVD/ LVD.…”

EAU-ESTRO-SIOG Guidelines on Prostate Cancer. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent

“…Provided that the tumour is not fixed, and not invading the urethral sphincter, RP combined with an ePLND is a reasonable first step in a multimodal approach. The estimated risk for pN+ is 15-40% [49].…”

“…The risk of having positive nodes is 3.7-20.1% [49]. An ePLND should be performed if the estimated risk for pN+ exceeds 5% [49].…”

“…The individual risk of finding positive lymph nodes can be estimated using pre-operative nomograms such as the Briganti nomogram, which has been externally validated [49]. A risk of nodal metastases over 5% is an indication to perform an extended pelvic lymph node dissection (ePLND).…”

Contemporary minimally‐invasive extended pelvic lymph node dissection for prostate cancer before curative radiotherapy: Prospective standardized analysis of complications

“…1 However, most PCa patients treated with RT undergo prostate-only or whole-pelvis RT based on their risk of LNI, as calculated by one of several nomograms. [2][3][4] Alternatively, these patients can undergo prior staging PLND to reliably determine nodal status. Whole-pelvis RT can then be limited to patients with LNI, thus reducing overtreatment.…”