Updated estimates of typical effective doses for common CT examinations in the UK following the 2011 national review

Shrimpton, Paul; Jansen, Jan; Harrison, John

doi:10.1259/bjr.20150346

Cited by 112 publications

(96 citation statements)

References 24 publications

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“…Although it is appreciated that probability of tumour induction increases in a linear fashion (11) in proportion to radiation dose, the interval required for tumour induction is not well understood. Therefore, the discordance between the high mean ED identified in this cohort and the lack of secondary tumour induction, may be accounted for by the relatively short review period of this study (8 years).…”

Section: Discussionmentioning

confidence: 99%

Radiological surveillance in multiple endocrine neoplasia type 1: a double-edged sword?

Casey

Saunders

Challis

et al. 2017

Endocrine Connections

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ContextMultiple endocrine neoplasia type 1 (MEN1) is a hereditary condition characterised by the predisposition to hyperplasia/tumours of endocrine glands. MEN1-related disease, moreover, malignancy related to MEN1, is increasingly responsible for death in up to two-thirds of patients. Although patients undergo radiological and biochemical surveillance, current recommendations for radiological monitoring are based on non-prospective data with little consensus or evidence demonstrating improved outcome from this approach. Here, we sought to determine whether cumulative radiation exposure as part of the recommended radiological screening programme posed a distinct risk in a cohort of patients with MEN1.Patients and study designA retrospective review of 43 patients with MEN1 attending our institution between 2007 and 2015 was performed. Demographic and clinical information including phenotype was obtained for all patients. We also obtained details regarding all radiological procedures performed as part of MEN1 surveillance or disease localisation. An estimated effective radiation dose (ED) for each individual patient was calculated.ResultsThe mean ED for the total patient cohort was 121 mSv, and the estimated mean lifetime risk of cancer secondary to radiation exposure was 0.49%. Patients with malignant neuroendocrine tumours (NETS) had significantly higher ED levels compared to patients without metastatic disease (P < 0.0022).ConclusionsIn MEN1, radiological surveillance is associated with clinically significant exposure to ionising radiation. In patients with MEN1, multi-modality imaging strategies designed to minimise this exposure should be considered.

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Section: Discussionmentioning

confidence: 99%

Radiological surveillance in multiple endocrine neoplasia type 1: a double-edged sword?

Casey

Saunders

Challis

et al. 2017

Endocrine Connections

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“…The effective dose of the HRCT scan was 0.93 mrem and that of the UH re-scan was 0.38 mrem, based on the average dose-length product reported by the scanner and published conversion factors [25].…”

Section: Scan Protocolmentioning

confidence: 99%

Clinical CT underestimation of the percentage volume occupied by cysts in patients with lymphangioleiomyomatosis

et al. 2020

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To evaluate the accuracy of cyst score measurements by standard high-resolution helical volume chest CT (HRCT) in patients with lymphangioleiomyomatosis (LAM), using a short z-length ultra-high resolution rescan (UH re-scan) as the reference. In cystic lung diseases, cyst score is derived from CT scans and defined as the percentage of the total lung parenchymal volume occupied by cysts, a biomarker which measures the severity of the disease. Methods: In a prospective study of 73 LAM patients, each patient received the standard HRCT chest scan and a short z-length UH re-scan. Cyst scores were acquired from both scans using a standard FDA-approved scoring software on the CT scanner. Results: The limited UH re-scan resolved small cysts that were not resolved in the HRCT. The HRCT-derived cyst scores were on average 59.6% of the reference values from the UH re-scan (p = 4.7e-25). The amount of underestimation by HRCT varied from patient to patient, with an inter-quartile range of 29.8% and standard deviation of 20.7%. The overall trend was more pronounced underestimation for patients with lower cyst scores. For patients whose reference cyst scores were below 15 (n = 29), the HRCT cyst scores were 46.9 ± 21.6% of reference values (p = 7.4e-12), while for the rest of the patients (n = 44) the HRCT cyst scores were 68.0 ± 15.3% of reference values (p = 1.2E-19). Reconstructing the HRCT images to the resolution of the UH re-scan further widened the spread of the discrepancy between HRCT and reference values due to increased image noise, and did not provide accurate cyst scores. Conclusion: Cyst scores derived from standard high-resolution helical volume chest CT significantly underestimates the percentage lung volume occupied by cysts. This inaccuracy needs to be taken into consideration when cyst score is used as part of the CT assessment of the patient's condition.

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“…It is calculated by multiplying DLP with a tissue-specific conversion factor. In this study the current conversion factor for cervical spine imaging of 0.0057 [22] was applied:…”

Section: Dosementioning

confidence: 99%

Periradicular Infiltration of the Cervical Spine: How New CT Scanner Techniques and Protocol Modifications Contribute to the Achievement of Low-Dose Interventions

Elsholtz

Kamp

Vahldiek

et al. 2018

Fortschr Röntgenstr

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Updated estimates of typical effective doses for common CT examinations in the UK following the 2011 national review

Abstract: Updated E/DLP coefficients and typical values of E for UK CT, and an appreciation of factors influencing these data.

Cited by 112 publications

References 24 publications

Radiological surveillance in multiple endocrine neoplasia type 1: a double-edged sword?

Radiological surveillance in multiple endocrine neoplasia type 1: a double-edged sword?

Clinical CT underestimation of the percentage volume occupied by cysts in patients with lymphangioleiomyomatosis

Periradicular Infiltration of the Cervical Spine: How New CT Scanner Techniques and Protocol Modifications Contribute to the Achievement of Low-Dose Interventions

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