Updated Brazilian genetic data, together with mutation rates, on 19 STR loci, including D10S1237.

Whittle, M.R.; Romano, Nara Lúcia; Negreiros, V A C

doi:10.1016/j.forsciint.2003.11.004

Cited by 27 publications

(26 citation statements)

References 12 publications

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“…Like other Brazilian populations, that of Midwestern Brazil is derived from the admixture of 3 main parental groups: Amerindian, European, particularly Portuguese, and Africans from sub-Saharan Africa. Thus, the overall distribution of the allele frequencies in the STR markers in various Brazilian populations is quite similar to the data obtained in this study (Ferreira da Silva et al, 2002;Silva et al, 2004;Whittle et al, 2004, Ferreira et al, 2005Leite et al, 2006;Rodrigues et al, 2007;São-Bento et al, 2008). These data could be incorporated to generate a regional molecular genetic population database for applications in forensic analysis, genetic linkage and population genetic studies.…”

Section: Resultssupporting

confidence: 84%

Short Communication Allelic frequencies and statistical data obtained from 15 STR loci in a population of the Goiás State

Vieira¹,

Silva²,

Gigonzac³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. Due to the miscegenation of the Brazilian population, the central region of Brazil was colonized by internal migration of individuals from different origins, who contributed to the genetic diversity existing in this population. The purpose of this study was to estimate population parameters based on the allele frequencies for 15 polymorphic autosomal short-tandem repeat (STR) loci present in the population of the State of Goiás in the central region of Brazil, and to compare the results with those of others from different Brazilian populations. DNA was obtained from a sample of 986 unrelated individuals by a commercial reagent kit and was quantified by spectrometry for later amplification in the thermocycler. These loci, commonly used in forensics and paternity testing, reflected Hardy-Weinberg equilibrium in this population. The D18S51 and Penta E loci had the highest number of alleles, while the observed heterozygosity reached the highest rates in FGA (0.920), D7S820 (0.870), and vWA (0.867) markers. Genetic diversity reached the highest levels in Penta E (0.906), Penta D (0.873), and D18S51 (0.860) markers, and the investigated forensic parameters showed high average values, with 93% power of discrimination, polymorphism information content of 78%, gene diversity of 79%, and observed heterozygosity of 79%. Similar to the other populations of Brazil, the population of the Midwest is derived from the admixture of 3 main parental groups: Amerindian, European, particularly Portuguese, and Africans from sub-Saharan Africa. In this context, the overall distribution of allele frequencies in the STR markers of various Brazilian populations is quite similar to the data obtained in this study.

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Section: Resultssupporting

confidence: 84%

Short Communication Allelic frequencies and statistical data obtained from 15 STR loci in a population of the Goiás State

Vieira¹,

Silva²,

Gigonzac³

et al. 2013

Genet. Mol. Res.

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“…The LRT analysis we performed assumes the distribution of paternal alleles was the same as the maternal. Although there are data strongly supporting a pattern of directional mating during South America's colonization, available data from the eight countries that contributed samples to our studies demonstrate that the frequency of random autosomal alleles in unrelated males and females from these countries is comparable, therefore our approach is valid [Sans et al, 1994;Gene et al, 1998;Figueroa et al, 2000;Chiurillo et al, 2003;Gonzalez-Andrade et al, 2003;MartinezEspin et al, 2003;Marignac et al, 2004;Whittle et al, 2004]. We suggest that the association of NSOFC and IRF6 in South Americans relates to ancestral origin that is independent among individuals with maternal lineage containing the mitochondrial DNA haplotype D. The mitochondrial DNA haplotype D is more frequent in a number of Native American subgroups (Aleuts, Amazonians, Andeans, and Patagonians) than it is in other subgroups.…”

mentioning

confidence: 73%

Interferon regulatory factor 6 (IRF6) is associated with oral‐facial cleft in individuals that originate in South America

Vieira

Cooper

Marazita

et al. 2007

American J of Med Genetics Pt A

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“…Brazilian genetic data on autosomal [8,9] and Ychromosome STRs [10][11][12] are already available, but few studies have been published regarding the X-STRs in Brazil [5,7,[13][14][15][16]. Thus, the aim of the current study was to analyze the 10 X-STRs standardized by the GHEP-ISFG [7] in capital cities of the southeastern region of Brazil (São Paulo, Rio de Janeiro, Vitória and Belo Horizonte).…”

Section: Introductionmentioning

confidence: 99%

Genetic profile characterization of 10 X-STRs in four populations of the southeastern region of Brazil

et al. 2010

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Ten X-chromosomal short tandem repeats (DXS8378, DXS9902, DXS7132, DXS9898, DXS6809, DXS6789, DXS7133, GATA172D05, GATA31E08 and DXS7423) were analyzed in four populations of the southeastern region of Brazil (São Paulo, Rio de Janeiro, Vitória and Belo Horizonte). No deviations from the Hardy-Weinberg equilibrium were observed for any of the analyzed loci in the four populations. The average diversity per locus varied between 68% for DXS8378, DXS7133, and DXS7423 and 83%, for DXS6809, with Rio de Janeiro being the most diverse population. Overall power of discrimination values in females varied between 0.99999999990 and 0.99999999997 and between 0.9999991 and 0.9999995 in males. These high values show the potential of this system for forensic application and relationships' testing in the studied groups. Genetic comparisons (exact tests of population differentiation and pairwise genetic distances) revealed significant differences between Brazilian and other populations from Europe, Latin America and Africa, as well as among different Brazilian populations.

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Updated Brazilian genetic data, together with mutation rates, on 19 STR loci, including D10S1237.

Cited by 27 publications

References 12 publications

Short Communication Allelic frequencies and statistical data obtained from 15 STR loci in a population of the Goiás State

Short Communication Allelic frequencies and statistical data obtained from 15 STR loci in a population of the Goiás State

Interferon regulatory factor 6 (IRF6) is associated with oral‐facial cleft in individuals that originate in South America

Genetic profile characterization of 10 X-STRs in four populations of the southeastern region of Brazil

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