Update on Wilms tumor

Aldrink, Jennifer H.; Heaton, Todd E.; Dasgupta, Roshni; Lautz, Timothy B.; Malek, Marcus M.; Abdessalam, Shahab; Weil, Brent R.; Rhee, Daniel S.; Baertschiger, Reto M.; Ehrlich, Peter F.

doi:10.1016/j.jpedsurg.2018.09.005

Cited by 78 publications

(69 citation statements)

References 64 publications

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“…Wilms tumor (nephroblastoma) is a solid kidney tumor that mainly affects children 1 . It is a tumor of embryonic origin that originates from abnormal differentiation in primitive cells during fetal nephrogenesis 2 .…”

Section: Introductionmentioning

confidence: 99%

“…Wilms tumor (nephroblastoma) is a solid kidney tumor that mainly affects children. 1 It is a tumor of embryonic origin that originates from abnormal differentiation in primitive cells during fetal nephrogenesis. 2 The incidence of Wilms tumor is higher in the United States compared to that of Wilms tumor in China, there being about 7 new cases per million children compared to 3.3 per million.…”

Section: Introductionmentioning

confidence: 99%

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Impact of YTHDF1 gene polymorphisms on Wilms tumor susceptibility: A five‐center case‐control study

Liu

Lin

Hua³

et al. 2021

Clinical Laboratory Analysis

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Background Wilms tumor is the most frequent renal malignancy in children. YTHDF1 is associated with the development of several kinds of cancers, yet whether common variants of the YTHDF1 gene influence Wilms tumor risk is unknown. We present, here, a hospital‐based case‐control study specifically designed to investigate the role of YTHDF1 genetic variants on Wilms tumor. Methods We successfully genotyped samples of 408 Wilms tumor cases and 1198 controls which were collected from five hospitals across China. The unconditional logistic regression was adopted to analyze the contributions of YTHDF1 gene single nucleotide polymorphisms (SNPs) to the risk of Wilms tumor. The odds ratio (OR) and 95% confidence interval (CI) were generated to evaluate the conferring risk of YTHDF1 gene SNPs (rs6011668 C>T, rs6090311 A>G). Results Neither of the two SNPs could contribute to the risk of Wilms tumor. A negative association was also detected in the combined effects of protective genotypes on Wilms tumor risk. The stratification analysis revealed that compared with those with CC genotype, rs6011668 CT/TT genotype was associated with increased Wilms tumor risk in those ≤18 months (OR = 1.54, 95% CI = 1.02–2.30, p = 0.038), and with decreased Wilms tumor risk in those >18 months (OR = 0.70, 95% CI = 0.50–0.97, p = 0.034). Conclusion Our present work sheds some light on the potential role of YTHDF1 gene polymorphisms on Wilms tumor risk.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impact of YTHDF1 gene polymorphisms on Wilms tumor susceptibility: A five‐center case‐control study

Liu

Lin

Hua³

et al. 2021

Clinical Laboratory Analysis

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“…They are a family of bicyclic chromopeptide lactones that attach two pentapeptide lactones of nonribosomal origin. Its use dates approximately 70 years ago, acting under several types of malignant human tumours, including nephroblastoma (Wilms’ tumour) and childhood rhabdomyosarcoma 67 – 69 , and has attracted attention for its potential to assist in the development growth of multi-drug resistance strains and inhibition of HIV-1 reverse transcriptase 44 , 70 , 71 .…”

Section: Discussionmentioning

confidence: 99%

Actinobacteria from Antarctica as a source for anticancer discovery

Silva

Crevelin

Souza

et al. 2020

Sci Rep

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Although many advances have been achieved to treat aggressive tumours, cancer remains a leading cause of death and a public health problem worldwide. Among the main approaches for the discovery of new bioactive agents, the prospect of microbial secondary metabolites represents an effective source for the development of drug leads. In this study, we investigated the actinobacterial diversity associated with an endemic Antarctic species, Deschampsia antarctica, by integrated culture-dependent and culture-independent methods and acknowledged this niche as a reservoir of bioactive strains for the production of antitumour compounds. The 16S rRNA-based analysis showed the predominance of the Actinomycetales order, a well-known group of bioactive metabolite producers belonging to the Actinobacteria phylum. Cultivation techniques were applied, and 72 psychrotolerant Actinobacteria strains belonging to the genera Actinoplanes,

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“…Wilms tumor (nephroblastoma) is the most common embryonal renal cancer in the pediatric population. 1 Wilms tumors primarily arise from abnormal renal precursor cells. 2 The annual incidence rate is approximately seven cases per million children in the USA and 3.3 per million in China.…”

Section: Introductionmentioning

confidence: 99%

Role of FTO gene polymorphisms in Wilms tumor predisposition: A five‐center case–control study

Hua

et al. 2021

The Journal of Gene Medicine

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Background: Wilms tumor is the most frequently occurring renal malignancy in pediatrics. The FTO gene exhibits a featured genetic contribution to cancer development.Nonetheless, its single nucleotide polymorphism (SNP) contribution to Wilms tumor remains unknown.Methods: In the present study, 402 Wilms tumor patients and 1198 healthy controls were successfully genotyped for FTO gene SNPs (rs1477196 G>A, rs9939609 T>A, rs7206790 C>G and rs8047395 A>G) using TaqMan SNP genotyping assays. Odds ratios (ORs) and 95% confidence intervals (CIs), generated from unconditional logistic regression, were applied to quantify the effects of FTO gene SNPs on Wilms tumor risk.Results: We found that the rs8047395 A>G polymorphism was significantly correlated with an increased risk for Wilms tumor (GG versus AA/AG: adjusted OR = 1.38, 95% CI = 1.04-1.85, p = 0.027). Carriers with 1 and 1-2 risk genotypes are more susceptible of developing Wilms tumor than those without risk genotypes. Stratified analysis of rs8047395 and risk genotypes revealed more significant relationships with Wilms tumor risk in certain subgroups. Preliminary functional annotations revealed that the rs8047395 A allele increases expression levels of the FTO gene as determined by expression quantitative trait locus analysis. Conclusions:The present study provides evidence that rs8047395 may regulate FTO gene expression and thus confer susceptibility to Wilms tumor. The candidate FTO gene rs8047395 A>G polymorphism identified in this study warrants independent investigation.

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Update on Wilms tumor

Cited by 78 publications

References 64 publications

Impact of YTHDF1 gene polymorphisms on Wilms tumor susceptibility: A five‐center case‐control study

Impact of YTHDF1 gene polymorphisms on Wilms tumor susceptibility: A five‐center case‐control study

Actinobacteria from Antarctica as a source for anticancer discovery

Role of FTO gene polymorphisms in Wilms tumor predisposition: A five‐center case–control study

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