Update on toxoplasmosis in poultry farming

Beck, Britta; Berberich, M.; Daugschies, Arwid

doi:10.17236/sat00334

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“…For example, feeding domestic cats on chickens infected with the parasite increases the chance of transferring oocysts to the cats. 8 In chickens' muscles, T. gondii transforms into cysts, which can then be transmitted to humans. 9 Transmission of T. gondii to humans can be congenital or acquired.…”

Section: Introductionmentioning

confidence: 99%

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Toxoplasma gondii triggers heterophil extracellular traps via NADPH oxidase, ERK_1/2 and P38 signalling pathways, glycolysis and autophagy in chickens

Chen

Jin

et al. 2023

Parasite Immunology

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Toxoplasma gondii is a zoonotic parasite with a global distribution. Heterophil extracellular traps (HETs) are a novel innate immune mechanism of chickens against pathogens, but whether T. gondii can induce HETs release in chickens has not been reported. The effects of T. gondii on heterophils viability were assessed by using Cell Counting Kit‐8. T. gondii‐induced HETs were observed and analysed by the immunofluorescence method. T. gondii‐induced reactive oxygen species (ROS) was determined by the DCFH‐DA method. The mechanisms underlying T. gondii‐triggered HETs were investigated by inhibitors and fluorescence microplate reader. T. gondii did not significantly affect heterophils viability at a 1:1 ratio within 1 h. It was demonstrated for the first time that T. gondii could induce HETs release in chicken, and the structure of HETs was comprised of DNA, elastase and citrullinated histone 3 (citH3). T. gondii increased ROS production in a dose‐dependent manner. Inhibitors of NADPH oxidase, extracellular signal‐regulated kinase 1/2 (ERK1/2) and P38 signalling pathways, glycolysis and autophagy significantly decreased the release of T. gondii‐induced HETs. Taken together, T. gondii can induce HETs release in chickens, and ROS, NADPH oxidase, ERK1/2 and P38 signalling pathways, glycolysis and autophagy participate in the process of HETs release, which provides new insights into the innate immune mechanism of chickens against T. gondii infection.

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Section: Introductionmentioning

confidence: 99%

“…Chickens are important players in T. gondii transmission. For example, feeding domestic cats on chickens infected with the parasite increases the chance of transferring oocysts to the cats 8 . In chickens' muscles, T. gondii transforms into cysts, which can then be transmitted to humans 9 .…”

Section: Introductionmentioning

confidence: 99%

Toxoplasma gondii triggers heterophil extracellular traps via NADPH oxidase, ERK_1/2 and P38 signalling pathways, glycolysis and autophagy in chickens

Chen

Jin

et al. 2023

Parasite Immunology

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Update on toxoplasmosis in poultry farming

Cited by 1 publication

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Toxoplasma gondii triggers heterophil extracellular traps via NADPH oxidase, ERK_1/2 and P38 signalling pathways, glycolysis and autophagy in chickens

Toxoplasma gondii triggers heterophil extracellular traps via NADPH oxidase, ERK_1/2 and P38 signalling pathways, glycolysis and autophagy in chickens

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Update on toxoplasmosis in poultry farming

Cited by 1 publication

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Toxoplasma gondii triggers heterophil extracellular traps via NADPH oxidase, ERK1/2 and P38 signalling pathways, glycolysis and autophagy in chickens

Toxoplasma gondii triggers heterophil extracellular traps via NADPH oxidase, ERK1/2 and P38 signalling pathways, glycolysis and autophagy in chickens

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Toxoplasma gondii triggers heterophil extracellular traps via NADPH oxidase, ERK_1/2 and P38 signalling pathways, glycolysis and autophagy in chickens

Toxoplasma gondii triggers heterophil extracellular traps via NADPH oxidase, ERK_1/2 and P38 signalling pathways, glycolysis and autophagy in chickens