Update on the role of plasmacytoid dendritic cells in inflammatory/autoimmune skin diseases

Saadeh, Dana; Kurban, Mazen; Abbas, Ossama

doi:10.1111/exd.12957

Cited by 70 publications

(108 citation statements)

References 133 publications

(204 reference statements)

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“…Plasmacytoid dendritic cells play a critical role in the initiation of the psoriatic immune response . We therefore tested the ability of GL to suppress the induction of type I IFNs by IMQ in pDCs.…”

Section: Resultsmentioning

confidence: 99%

Gold lotion from citrus peel extract ameliorates imiquimod‐induced psoriasis‐like dermatitis in murine

Lin

Pan

et al. 2018

J Sci Food Agric

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Section: Resultsmentioning

confidence: 99%

Gold lotion from citrus peel extract ameliorates imiquimod‐induced psoriasis‐like dermatitis in murine

Lin

Pan

et al. 2018

J Sci Food Agric

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“…In cell culture models, FasL induces the characteristic hypergranulosis while IFN‐γ causes keratinocyte apoptosis with cytoid body formation, and ICAM‐1 expression . Increasing evidence suggests an additional and important role for plasmacytoid dendritic cells and IFN‐α in the pathogenesis of lichenoid diseases, possibly via recruitment and amplification of interface dermatitis …”

Section: An Immunologic View At Inflammatory Skin Diseasesmentioning

confidence: 99%

Immune response patterns in non‐communicable inflammatory skin diseases

Eyerich

2018

Acad Dermatol Venereol

125

143

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Non‐communicable inflammatory skin diseases (ncISD) such as psoriasis or atopic eczema are a major cause of global disease burden. Due to their impact and complexity, ncISD represent a major challenge of modern medicine. Dermatology textbooks describe more than 100 different ncISD based on clinical phenotype and histological architecture. In the last decades, this historical description was complemented by increasing molecular knowledge – and this knowledge is now being translated into specific therapeutics. Combining the enormous advances made in lymphocyte immunology and molecular genetics with clinical and histological phenotyping reveals six immune response patterns of the skin – type I immune cells cause the lichenoid pattern characterized by immune‐mediated cell death of keratinocytes; type II immune cells underlie the eczematous pattern with impaired epidermal barrier, infection and eosinophils as well as the bullous pattern with loss of epithelial integrity; Th17 cells and ILC3 mediate the psoriatic pattern characterized by acanthosis, high metabolic activity and neutrophils; dysbalance of regulatory T cells causes either the fibrogenic pattern with rarefication of cells and dermal thickening or the granulomatous pattern defined by formation of granulomas. With more and more specific therapeutic agents approved, classifying ncISD also according to their immune response pattern will become highly relevant. This review defines the six immune response patterns of ncISD and highlights therapeutic strategies targeting key lymphocyte mediators.

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“…These studies may focus on mechanisms involving plasmacytoid dendritic cells (pDCs), the most potent producers of type I IFN. Chronic pDC activation is known to contribute to the initiation of different autoimmune skin disorders, including systemic lupus erythematosus, psoriasis, vitiligo and alopecia aerata [58]. Furthermore, the occurrence of a feedback regulatory loop does exist between DCs and FOXP3+ Treg cells, which are essential for maintaining self tolerance [59].…”

Section: Discussionmentioning

confidence: 99%

Association between rs2294020 in X-linked CCDC22 and susceptibility to autoimmune diseases with focus on systemic lupus erythematosus

D’Amico

Skarmoutsou

et al. 2017

Immunology Letters

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Autoimmune diseases often share common susceptibility genes. Most genetic variants associated with susceptibility to systemic lupus erythematosus are also associated with other autoimmune diseases. The X-linked variant rs2294020 is positioned in exon 7 of the CCDC22 gene. The encoded protein functions in the regulation of NF-kB, a master regulator in immune response. The aim of this study is to investigate whether the rs2294020 polymorphism may be a general susceptibility factor for autoimmunity. We evaluated case-control association between the occurrence of rs2294020 and different autoimmune diseases, including new data for systemic lupus erythematosus and previous genome-wide association studies (GWAS) (though most did not analyse the X chromosome) of psoriasis, celiac disease, Crohn’s disease, ulcerative colitis, multiple sclerosis, vitiligo, type-1 diabetes, rheumatoid arthritis, and ankylosing spondylitis. Cases from patients affected by amyotrophic lateral sclerosis and type-2 diabetes were also included in the study. We detected nominal significant associations of rs2294020 with systemic lupus erythematosus (additive model test: p=0.01), vitiligo (p =0.016), psoriasis (p =0.038), and in only one of two studies of multiple sclerosis (p =0.03). Our results suggest that rs2294020 is associated with the risk of several autoimmune diseases in European populations, specifically with diseases that present themselves, among else, in the skin.

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Update on the role of plasmacytoid dendritic cells in inflammatory/autoimmune skin diseases

Cited by 70 publications

References 133 publications

Gold lotion from citrus peel extract ameliorates imiquimod‐induced psoriasis‐like dermatitis in murine

Gold lotion from citrus peel extract ameliorates imiquimod‐induced psoriasis‐like dermatitis in murine

Immune response patterns in non‐communicable inflammatory skin diseases

Association between rs2294020 in X-linked CCDC22 and susceptibility to autoimmune diseases with focus on systemic lupus erythematosus

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