Update on the role and therapeutic potential of polycomb repressive complexes in (biliary tract) cancer

Neureiter, Daniel; Kiesslich, Tobias; Ritter, Markus; Mayr, Christian

doi:10.1080/14728222.2018.1406923

Cited by 2 publications

(1 citation statement)

References 21 publications

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“…Several cancers have increased transcription of almost all PcG genes; these cancers include cholangiocarcinoma of the bile duct (CHOL), diffuse large B-cell lymphoma (DLBCL), pancreatic cancer (PAAD) and thymoma (THYM). The upregulation of Polycomb subunits has been confirmed in cholangiocarcinoma and pancreatic cancer ( 177 , 178 ) but has yet to be investigated in thymomas. While therapeutic targeting of PcG has not been extensively explored in any of these cancers, recent studies in pancreatic cancer indicate that targeting EZH2 or BMI1 may be effective in certain aggressive subtypes or cell populations ( 179 , 180 ).…”

Section: Pcg Proteins In Cancermentioning

confidence: 99%

Polycomb group proteins in cancer: multifaceted functions and strategies for modulation

et al. 2021

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Polycomb repressive complexes (PRCs) are a heterogenous collection of dozens, if not hundreds, of protein complexes composed of various combinations of subunits. PRCs are transcriptional repressors important for cell-type specificity during development, and as such, are commonly mis-regulated in cancer. PRCs are broadly characterized as PRC1 with histone ubiquitin ligase activity, or PRC2 with histone methyltransferase activity; however, the mechanism by which individual PRCs, particularly the highly diverse set of PRC1s, alter gene expression has not always been clear. Here we review the current understanding of how PRCs act, both individually and together, to establish and maintain gene repression, the biochemical contribution of individual PRC subunits, the mis-regulation of PRC function in different cancers, and the current strategies for modulating PRC activity. Increased mechanistic understanding of PRC function, as well as cancer-specific roles for individual PRC subunits, will uncover better targets and strategies for cancer therapies.

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