Update on the Management of BK Virus Infection

Saleh, Ahmed; Khedr, Mohamed Salah El Din; Ezzat, Abeer; Takou, Anna; Halawa, Ahmed

doi:10.6002/ect.2019.0254

Cited by 10 publications

(12 citation statements)

References 90 publications

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“…Switching immunosuppression therapies led to clinical remission in 20 of 22 (90.9%) patients in our study (Table 3), consistent with data from previous case series 7,22,42 . Overall, we observed mycophenolate mofetil treatment modification in nearly two‐thirds of the patients with microsporidiosis, as described in other studies of opportunistic diseases in kidney transplant recipients 43,44 . In our work, fumagillin therapy with or without ∆IS yielded excellent clinical and parasite response rates (Figure 1).…”

Section: Discussionsupporting

confidence: 90%

“…7,22,42 Overall, we observed mycophenolate mofetil treatment modification in nearly two-thirds of the patients with microsporidiosis, as described in other studies of opportunistic diseases in kidney transplant recipients. 43,44 In our work, fumagillin therapy with or without ∆IS yielded excellent clinical and parasite response rates (Figure 1). Only one patient did not achieve clinical remission, but the stool follow-up examination was negative, while two had remaining microsporidia in their stool.…”

Section: Discussionmentioning

confidence: 53%

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Epidemiological and clinical study of microsporidiosis in French kidney transplant recipients from 2005 to 2019: TRANS‐SPORE registry

Dumond

Aulagnon

Étienne

et al. 2021

Transplant Infectious Dis

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 53%

Epidemiological and clinical study of microsporidiosis in French kidney transplant recipients from 2005 to 2019: TRANS‐SPORE registry

Dumond

Aulagnon

Étienne

et al. 2021

Transplant Infectious Dis

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“…As a result, pre-and posttransplantation BKV serology examinations should be taken into account in such cases. However, the usefulness of the mentioned approach is controversial (28).…”

Section: Discussionmentioning

confidence: 99%

Higher Viral Load of Polyomavirus Type BK but not JC among Renal Transplant Recipients in Comparison to Donors

et al. 2022

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Scan to discover onlineBackground & Objective: Polyomaviruses types BK and JC and Cytomegalovirus (CMV) have been shown to be related to kidney transplantation complications. This study aimed to assess the prevalence of these viruses in patients receiving kidney transplantation. Methods: This cross-sectional study was performed on 40 kidney transplant recipients and 44 donors. Urine samples were used for the extraction of viral DNA. The prevalence of JC and BK viruses and their viral loads were determined by real-time polymerase chain reaction.Results: JC and BK viruses were identified in 31% and 92.3% of all subjects, respectively. The frequency of JC and BK cases was not statistically different between the recipient and donor groups (P>0.05). All patients in the donor group and 96.8% of the recipients were positive for CMV IgG antibody. The mean viral load of BK in donors and recipients was 4.5×10 10 and 3.3×10 11 copies, respectively. The mean viral load of JC was 8.6×10 7 copies in donors and 2.9×10 8 copies in recipients. The distribution of BKV was significantly higher in recipients than donors (P=0.001), while no difference was observed between the two studied groups for JCV. Conclusion:This study showed a relatively high prevalence of BK and JC viruria in both renal transplant donors and recipients. The viral load for BKV, but not JCV, was higher in recipients than in donors.

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“…The theoretical support for this conclusion could be attributed to BKV infection mainly occurred in male patients, while BKV infection (BKV viruria and viremia) can increase the occurrence of HC. 27,28 Moreover, estrogen was reported to play a role in protecting the bladder mucosa, which may contribute to the low incidence of BKV-HC in female patients. 29 The sources of stem cells generally include the bone marrow, peripheral blood, and umbilical cord blood.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for BK virus‐associated hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation: A systematic review and meta‐analysis

Zhou,

Zhang,

Fan

et al. 2023

Clinical Transplantation

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Objective and BackgroundBK virus‐associated hemorrhagic cystitis (BKV‐HC) is an intractable complication leading to higher mortality and prolonged hospitalization among allogeneic hematopoietic stem cell transplantation (allo‐HCT) recipients. Therefore, identifying the potential risk factors of BKV‐HC after allo‐HCT is crucial to improve prognosis and for early prevention. However, the risk factors for BKV‐HC remain debatable. Therefore, we conducted a systematic review and meta‐analysis to identify the risk factors for BKV‐HC, for early prevention of the occurrence of BKV‐HC and to improve the quality of life and prognosis of allo‐HCT recipients.MethodsWe searched relevant studies from PubMed, EMBASE, and the Cochrane Library up to February 2023. The odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) of all risk factors were calculated to evaluate their effects on the occurrence of BKV‐HC.ResultsOverall, 11 studies involving 2556 allo‐HCT recipients were included in this meta‐analysis. All included studies were retrospective and published between 2013 and 2022. We found that male sex (OR = 1.32; 95% CI, 1.07–1.62; p = .009, I2 = 34%), haploidentical donor (OR = 1.84; 95% CI, 1.18–2.87; p = .007, I2 = 23%), myeloablative conditioning (OR = 1.76; 95% CI, 1.36–2.28; p < .0001, I2 = 45%), acute graft versus host disease (aGVHD) (OR = 2.73; 95% CI, 2.02–3.69; p < .0001, I2 = 46%), chronic graft versus host disease (cGVHD) (OR = 1.71; 95% CI, 1.12–2.60; p = .01, I2 = 0%), and cytomegalovirus (CMV) reactivation (OR = 3.13; 95% CI, 1.12–8.78; p = .03, I2 = 79%) were significantly associated with BKV‐HC in the univariable analysis.ConclusionsOur meta‐analysis indicated that male sex, haploidentical donor, myeloablative conditioning, aGVHD, cGVHD, and CMV reactivation were potential risk factors for BKV‐HC.

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Update on the Management of BK Virus Infection

Cited by 10 publications

References 90 publications

Epidemiological and clinical study of microsporidiosis in French kidney transplant recipients from 2005 to 2019: TRANS‐SPORE registry

Epidemiological and clinical study of microsporidiosis in French kidney transplant recipients from 2005 to 2019: TRANS‐SPORE registry

Higher Viral Load of Polyomavirus Type BK but not JC among Renal Transplant Recipients in Comparison to Donors

Risk factors for BK virus‐associated hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation: A systematic review and meta‐analysis

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