Update on the epidemiology, risk factors, and disease outcomes of systemic lupus erythematosus

Gergianaki, Irini; Bortoluzzi, Alessandra; Βertsias, George

doi:10.1016/j.berh.2018.09.004

Cited by 97 publications

(94 citation statements)

References 104 publications

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“…Chronic inflammation stimulated by environmental and genetic factors is a common characteristic in most autoimmune diseases including SLE (10,11). The immune system of SLE patients is aberrantly activated by autoantigens, resulting in immune complex deposition, complement system activation, and chronic inflammation (1,2,6,7). Additionally, several inflammatory markers, such as C-reactive protein, erythrocyte sedimentation rate, and interferon, are positively associated with SLE progression.…”

Section: ' Discussionmentioning

confidence: 99%

“…SLE is more prevalent in women of reproductive age than in men (3)(4)(5). Although the etiology and pathogenesis of SLE have not been fully elucidated, the breakdown of immune tolerance induced by environmental stimulation and genetic factors is widely reported to play a core role in SLE (1,2,6,7). The typical characteristics of SLE mainly include autoantibody production, aberrant complement system activation, immune complex deposition, and chronic inflammation, usually leading to multiple organ damage as well as diverse clinical manifestations (1,2,6,7).…”

Section: ' Introductionmentioning

confidence: 99%

“…However, it holds great significance in identifying reliable, practical, and economical biomarkers to assist in diagnosing SLE and quantifying the disease activity of SLE patients. The immune system of SLE patients is abnormally activated by autoantigens, which results in immune complex deposition and complement system activation, followed by chronic inflammation (1,2,6,7,9). Furthermore, chronic inflammation stimulated by environmental and genetic factors is a common characteristic of autoimmune diseases including SLE (10,11).…”

Section: ' Introductionmentioning

confidence: 99%

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Relationship between Neutrophil-to-Lymphocyte Ratio and Systemic Lupus Erythematosus: A Meta-analysis

Wang¹,

Wang²,

Jia³

et al. 2020

Clinics

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Systemic lupus erythematosus (SLE) is a chronic systematic autoimmune disease. Current methods of diagnosing SLE or evaluating its activity are complex and expensive. Numerous studies have suggested that neutrophil-tolymphocyte ratio (NLR) is closely correlated with the presence of SLE and its activity, suggesting that it may serve as a diagnostic and monitoring indicator for SLE. Therefore, we performed a meta-analysis to systematically assess the association between NLR and SLE. We performed a literature search until 12 April 2019 in the PubMed, Web of Science, and China National Knowledge Infrastructure databases. Cross-sectional studies comparing the NLR of SLE patients versus those of healthy controls, of active versus inactive SLE patients, and of SLE patients with versus without lupus nephritis were considered for inclusion. Mean intergroup NLR differences were estimated using standardized mean differences and their 95% confidence intervals. Study quality was assessed using the Agency for Healthcare Research and Quality instrument for cross-sectional studies. Fourteen studies with 1,781 SLE patients and 1,330 healthy controls were included in this meta-analysis. The pooled results showed that the NLR was significantly higher in SLE patients than in healthy controls, in active SLE patients than in inactive SLE patients, and in SLE patients with lupus nephritis than in those without lupus nephritis. NLR may be an indicator for monitoring disease activity and reflecting renal involvement in SLE patients. Nevertheless, more high-quality studies are warranted to further validate our findings.

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Section: ' Discussionmentioning

confidence: 99%

Section: ' Introductionmentioning

confidence: 99%

Section: ' Introductionmentioning

confidence: 99%

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Relationship between Neutrophil-to-Lymphocyte Ratio and Systemic Lupus Erythematosus: A Meta-analysis

Wang¹,

Wang²,

Jia³

et al. 2020

Clinics

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“…Estimates on the worldwide incidence and prevalence of lupus revealed that the highest incidence was found in North America, while the lowest rates have been reported in Northern Australia [2]. Interestingly, a registry from the island of Crete reported that the overall age-adjusted/sex-adjusted incidence is growing among males [3].…”

Section: Introductionmentioning

confidence: 99%

Introductory Chapter: Recent Advances in Systemic Lupus Erythematosus

Lionaki¹,

Boletis²

2020

Lupus - New Advances and Challenges

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environmental factors and the genetic profile of each individual appear to be of great importance with respect to the onset and the progression of this disorder [7,8]. Given these circumstances, we consider systemic lupus erythematosus a challenging field of research, which enquires continuing updating in order to illustrate all current knowledge regarding disease pathogenesis and provide guidelines for clinical practice employing all newer immunosuppressive agents.

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“…Interestingly, some of the uncommon RMDs, such as Systemic Lupus Erythematosus, are not considered as rare as they used to, in the past [16,17]. Yet, for a PCP, it is not only the cases that a decision to referral with "possible SLE diagnosis" will be made, but all the cases that SLE is suspected, with low probability, and the patient should be reassured or re-evaluated [18].…”

mentioning

confidence: 99%

The Burden of Rheumatic Diseases in the Community: Raising Awareness in Primary Care

2018

PEGH

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Update on the epidemiology, risk factors, and disease outcomes of systemic lupus erythematosus

Cited by 97 publications

References 104 publications

Relationship between Neutrophil-to-Lymphocyte Ratio and Systemic Lupus Erythematosus: A Meta-analysis

Relationship between Neutrophil-to-Lymphocyte Ratio and Systemic Lupus Erythematosus: A Meta-analysis

Introductory Chapter: Recent Advances in Systemic Lupus Erythematosus

The Burden of Rheumatic Diseases in the Community: Raising Awareness in Primary Care

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