Update on the epidemiology, risk factors and disease outcomes of osteoarthritis

O’Neill, Terence W; McCabe, Paul S.; McBeth, John

doi:10.1016/j.berh.2018.10.007

Cited by 329 publications

(289 citation statements)

References 137 publications

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“…Pain may also be experienced by the hip osteoarthritis patient due to a variety of local immune responses [50] [51] [52], in addition to persistent progressive inflammatory processes [43], and altered muscle activation patterns, poorly timed muscle responses, and excess or aberrant joint motion [52] due to ligamentous damage [43] that may induce pain and foster its persistence. Pain may also arise as a result of physiological changes to the nerves themselves, as well as the reactivity of nerves that produce painful stimuli [ [62].…”

Section: Sourcesmentioning

confidence: 99%

Hip Joint Osteoarthritis Pain Sources and Control

Marks¹

2020

PST

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Hip joint osteoarthritis, a widespread disabling disease with no known cause, produces considerable bouts of intractable pain as a result of multiple disease associated problems. This paper examines some sources of osteoarthritic hip joint pain, a poorly understood topic at best. Presented in three parts are data retrieved from several sources, including animal models. It is concluded that to improve the effectiveness of treatments designed to minimize hip osteoarthritis pain, a better understanding of the diverse origins of hip joint pain, and hip joint neurology, may permit the development of more precise as well as targeted pain strategies.

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Section: Sourcesmentioning

confidence: 99%

Hip Joint Osteoarthritis Pain Sources and Control

Marks¹

2020

PST

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“…Провідне місце серед захворювань займають патології опорно-рухової системи, серед яких найбільш розповсюдженими є хвороби суглобів, які призводять до деградації хрящової тканини та розвитку запалення. Наслідком цих змін є системні ускладнення, прогресуюча інвалідність, що в цілому спричинює високі соціально-економічні витрати [1].…”

Section: тварин умертвляли на 30 добу після початку експерименту згідunclassified

Oxidative modification of proteins in rat serum under experimental osteoarthrosis and long-term administration of a multiprobiotic

et al. 2019

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The aim of the study was to investigate the effect of multiprobiotics on the content of products of oxidative modification of proteins and the level of sulfhydryl groups in blood serum of rats during monoiodoacetate-induced osteoarthritis. The study was carried out on white non-linear, sexually mature male rats (weight 180-240 g), according to general ethical principles of experiments on animals. All animals were divided into four experimental groups. The first group - Control: animals got injection into knee ligament 0.05 ml of 0.9% NaCl solution on the first day of the experiment and then got intragastric administration 1 ml of drinking water per 1 kg of the animal weight daily for 14 days from the 8th to 22nd days. The second group - Multiprobiotic: animals got injection into knee ligament 0.05 ml of 0.9% NaCl solution on the first day of the experiment and then got intragastric administration 140 mg/kg of multiprobiotic Symbiter® (Prolisok ", Ukraine) diluted in 1 ml of drinking water per 1 kg of animal weight. The third group, MIA-induced OA: animals got injection into knee ligament 1 mg of sodium monoiodacetate, dissolved in 0.05 ml of 0.9% NaCl on the first day of the experiment and then got intragastric administration 1 ml of drinking water per 1 kg of the animal weight daily for 14 days from the 8th to 22nd days. The fourth group – MIA-induced OA + Multiprobiotic: animals got injection into knee ligament 0.05 ml of 1 mg of sodium monoiodacetate, dissolved in 0.05 ml of 0.9 % NaCl on the first day of the experiment and then got intragastric administration 140 mg/kg of multiprobiotic diluted in 1 ml of drinking water per 1 kg of animal weight. All animals were killed on day 30 of the experiment, according to the protocol of the ethics committee with rapid blood sampling. The content of the products of oxidative modification of proteins (OMP) and oligopeptides was determined by the level of carbonyl derivatives that were detected in reaction with 2,4-initrophenylhydrazine. The level of total, protein-bound and non-protein sulfhydryl (SH) -groups was measured by the Elman method. It has been established that MIA-induced OA disturbed oxidative-antioxidant balance of the rat serum: the content of the products of oxidative modification of proteins increases and the content of sulfhydryl groups decreases in the serum. It was shown that with the long-term administration of multiprobiotics in animals with MIA-induced OA, the above indicators were restored.

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“…Osteoarthritis (OA) is the most common worldwide chronic rheumatic disease and the main culprit of disability among the middle-aged and elderly [1][2][3][4][5][6][7][8]. It is characterized by progressive articular cartilage degradation.…”

Section: Introductionmentioning

confidence: 99%

Caffeine, a Risk Factor for Osteoarthritis and Longitudinal Bone Growth Inhibition

Guillán-Fresco

Franco-Trepat

Alonso-Pérez

et al. 2020

JCM

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Osteoarthritis (OA), the most common chronic rheumatic disease, is mainly characterized by a progressive degradation of the hyaline articular cartilage, which is essential for correct joint function, lubrication, and resistance. Articular cartilage disturbances lead to joint failure, pain, and disability. Hyaline cartilage is also present in the growth plate and plays a key role in longitudinal bone growth. Alterations of this cartilage by diverse pathologies have been related to longitudinal bone growth inhibition (LBGI), which leads to growth retardation. Diet can play a crucial role in processes involved in the OA and LBGI’s onset and evolution. Specifically, there is ample evidence pointing to the negative impacts of caffeine consumption on hyaline cartilage. However, its effects on these tissues have not been reviewed. Accordingly, in this review, we summarize all current knowledge in the PubMed database about caffeine catabolic effects on articular and growth plate cartilage. Specifically, we focus on the correlation between OA and LBGI with caffeine prenatal or direct exposure. Overall, there is ample evidence indicating that caffeine intake negatively affects the physiology of both articular and growth plate cartilage, increasing consumers predisposition to suffer OA and LBGI. As a result, caffeine consumption should be avoided for these pathologies.

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Update on the epidemiology, risk factors and disease outcomes of osteoarthritis

Cited by 329 publications

References 137 publications

Hip Joint Osteoarthritis Pain Sources and Control

Hip Joint Osteoarthritis Pain Sources and Control

Oxidative modification of proteins in rat serum under experimental osteoarthrosis and long-term administration of a multiprobiotic

Caffeine, a Risk Factor for Osteoarthritis and Longitudinal Bone Growth Inhibition

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