Ti-10wt.%Cu sintered alloy was prepared by apowder metallurgy method to obtain strong antibacterial property. In order to optimize the deformation processing, the hot deformation behaviour of Ti-10wt.%Cu sintered alloy was investigated in this paper. The deformation temperature was set between 800°C to 1000°C and the strain rate was set in a range of 0.008 s−1 to 5s−1. The microstructure of the deformed alloy were observed in order to reveal the effect of the hot deformation process on the microstructure. The results showed that the Ti2Cu phase distributed homogeneously with the increasing of the deformation temperature and decreased with the increasing of the strain rate. It was concluded that the final optimized deformation process was: a deformation temperature range of 850°C to 950°C, and a strain rate of 0.1s−1 to 0.5s−1.